36776-43-9Relevant academic research and scientific papers
Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads
Hu, Nvdan,Kong, Wenlong,Li, Shengkun,Song, Baoan,Wang, Xia
supporting information, (2021/10/16)
The diversity of drimane hydroquinones was significantly expanded by the facile construction of (+)-chromazonarol relevant natural products, isomers, and analogues for the discovery of new pharmaceutical leads. The structure-activity relationship of (+)-c
An unprecedented deoxygenation protocol of benzylic alcohols using bis(1-benzotriazolyl)methanethione
Kumar, Dhananjay,Singh, Anoop S.,Tiwari, Vinod K.
, p. 31584 - 31593 (2015/04/22)
A facile and regioselective two-step protocol for the deoxygenation of benzylic alcohols using bis(benzotriazole)methanethione has been devised. Benzotriazole derivatives, namely, benzyloxythioacylbenzotriazoles (ROCSBt), on reaction with silanes or Bu3SnH under microwave irradiation or conventional heating undergo a free radical β-scission of C-O bond instead of N-N bond (benzotriazole ring cleavage) to afford a deoxy product. The methodology has various applications because it selectively deoxygenates benzylic alcohols with the aid of a relatively nontoxic (TMS)3SiH reagent as an acceptable alternate to Bu3SnH.
The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products
Iijima, Daisuke,Tanaka, Daisuke,Hamada, Motoko,Ogamino, Takahisa,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 5469 - 5471 (2007/10/03)
SB87-Cl 1, an inhibitor of testosterone-5α-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC=37ng/mL) and VRE (MIC=78ng/mL), were novel bioactive benzophenone natural products. Total synthesis of 1 and 2 has been successfully accomplished. The common synthetic precursor 18 of 1 and 2, was successfully obtained by the coupling of 8 with 12.
