39803-51-5Relevant academic research and scientific papers
The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle
Jacobsen, Kristian M.,Keiding, Ulrik B.,Clement, Lise L.,Schaffert, Eva S.,Rambaruth, Neela D. S.,Johannsen, Mogens,Drickamer, Kurt,Poulsen, Thomas B.
, p. 647 - 652 (2015/04/27)
We demonstrate that the natural product brartemicin, a newly discovered inhibitor of cancer cell invasion, is a high-affinity ligand of the carbohydrate-recognition domain (CRD) of the C-type lectin mincle. Recent studies have revealed that mincle is a ke
Synthesis of Echinotinctone, A Fungal Fluorone Pigment
Rueth, Matthias,Steglich, Wolfgang
, p. 677 - 680 (2007/10/03)
Echinotinctone (3) is formed by acid-catalyzed condensation of 1,2,4-trihydroxytoluene (1) with orcylaldehyde (2), a reaction mimicking the probable biosynthesis. A more efficient stepwise synthesis proceeds via the benzophenone intermediate 11, which can be converted to 2,6-dihydroxy-1,8-dimethyl-3H-xanthenn-3-one (3) by LiAlH4 reduction and subsequent acid-catalyzed ring closure.
Total synthesis of everninomicin 13,384-1 - Part 2: Synthesis of the FGHA2 fragment
Nicolaou,Mitchell, Helen J.,Fylaktakidou, Konstantina C.,Rodriguez, Rosa Maria,Suzuki, Hideo
, p. 3116 - 3148 (2007/10/03)
The stereoselective synthesis of everninomicin's 13,384-1 (1) FGHA2 fragment (2) in a suitable form for incorporation into the final target (1) is described. The construction of the FG 1,1′-disaccharide linkage relied on a new method based on tin-acetal chemistry, while for the GH orthoester bridge, a number of approaches were explored. Final success for the latter construction came when a novel 1,2-phenylseleno migration reaction was applied to couple rings G and H, followed by ketene acetal and orthoester formation.
