370555-59-2

Upstream product

• 100-39-0 benzyl bromide 
• 1131570-52-9 3-methyl-1-(phenylmethoxy)-3-(1,2,4-trioxolan-3-yl)butane 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 68972-96-3 (Z)-1,4-dibenzyloxy-2-butene 
• 54555-84-9 benzyl iodoethyl ether 
• 823180-17-2 methyl 4-(benzyloxy)-2,2-dimethylbutanoate 
• 374077-59-5 4-benzyloxy-2,2-dimethyl-butyric acid ethyl ester 

Downstream Products

• 374077-57-3 2-(1,1-Dimethyl-3-(2-nitrophenylselenyl)propyl)-1,4-naphthalenedione 
• 374077-58-4 1-(3,3-dimethyl-pent-4-ynylselanyl)-2-nitro-benzene 
• 67099-42-7 3,3-Dimethyl-5-benzyloxy-1-pentin 
• 823180-03-6 (((5,5-diiodo-3,3-dimethylpent-4-enyl)oxy)methyl)benzene 
• 370555-60-5 4-(benzyloxy)-2,2-dimethylbutanal 

Relevant academic research and scientific papers

EXTERNALLY MASKED NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE

Masked nitrogen-substituted and oxygen-substituted neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.

Highly efficient two-step synthesis of C-sp3-centered geminal diiodides

(Chemical Equation Presented) Trisubstituted gem-diiodoalkenes of functionalized chains are efficiently reduced to the corresponding terminal geminal diiodides in high yields upon treatment with the diazene precursor, diethyl 4-(hydrazinosulfonyl)-benzyl phosphonate.

Novel use of a selenoalkyne within untraditionally mild D?tz benzannulation processes; total synthesis of a Calceolaria andina L. natural hydroxylated naphthoquinone

A total synthesis of the Calceolaria andina L. extract 2-(1,1-dimethyl-2-propenyl)-3-hydroxy-1,4-naphthalenedione is described incorporating the first reported D?tz benzannulation of a selenoalkyne. Importantly, it has been shown that it is possible to effect this annulation at ambient temperature under dry state conditions with a significant improvement in cyclisation yield.