37074-38-7

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-METHYLACETOPHENONE is used as a building block for the production of active pharmaceutical ingredients. It plays a crucial role in the synthesis of various medications, contributing to the development of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-METHYLACETOPHENONE is utilized as an intermediate in the synthesis of various agrochemicals. This helps in the development of effective products for crop protection and enhancement of agricultural yields.
Used in Organic Compounds Synthesis:
4-CHLORO-2-METHYLACETOPHENONE is employed as an intermediate for the synthesis of a wide range of organic compounds. Its versatility in undergoing various chemical reactions makes it a valuable component in organic chemistry.
Used in Fragrance Industry:
4-CHLORO-2-METHYLACETOPHENONE is also used in the manufacture of fragrances and other fine chemicals. Its unique properties allow it to contribute to the creation of various scent profiles used in perfumes, cosmetics, and other fragranced products.
It is important to handle 4-CHLORO-2-METHYLACETOPHENONE with care, as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes. Proper safety measures should be taken during its use and manipulation to ensure the well-being of individuals and the environment.

Upstream product

• 21900-44-7 4-chloro-2-methylbenzoyl chloride 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 89587-46-2 4-Chloro-N-(2-dimethylamino-ethyl)-N-methyl-benzamide 
• 108-41-8 1-chloro-3-methylbenzene 
• 75-36-5 acetyl chloride 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 74-88-4 methyl iodide 
• 108-24-7 acetic anhydride 
• 917-64-6 methyl magnesium iodide 
• 50712-68-0 4-chloro-2-methylbenzonitrile 

Downstream Products

• 89-20-3 4-chlorophthalic acid 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 74346-25-1 1,1-Dichloro-1-(4-chloro-2-methylphenyl)ethane 
• 74331-71-8 1-(4-Chloro-2-methylphenyl)acetylene 
• 1046469-44-6 1-[1-(4-chloro-2-methylphenyl)-vinyl]-pyrrolidine 
• 478869-16-8 3-(4-chloro-2-methyl-phenyl)-2,5-dimethyl-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 478869-00-0 4-amino-5-(4-chloro-2-methyl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 478869-24-8 7-chloro-3-(4-chloro-2-methyl-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidine 
• 478868-84-7 5-(4-chloro-2-methyl-phenyl)-1-methyl-4-nitroso-1H-pyrazole-3-carboxylic acid ethyl ester 
• 478868-76-7 4-(4-Chloro-2-methyl-phenyl)-3-[(Z)-hydroxyimino]-2,4-dioxo-butyric acid ethyl ester 
• 74346-27-3 1-(4-Chloro-2-methylphenyl)vinyl tosylate 
• 74346-26-2 1-(4-Chloro-2-methylphenyl)vinyl bromide 
• 478868-69-8 4-(4-chloro-2-methyl-phenyl)-2,4-dioxo-butyric acid ethyl ester 

Relevant academic research and scientific papers

Aluminum dodecatungstophosphate (AlPW12O40) as a non-hygroscopic Lewis acid catalyst for the efficient Friedel-Crafts acylation of aromatic compounds under solvent-less conditions

Stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW 12O40), which is prepared easily from cheap and commercially available compounds was found to be an effective catalyst for Friedel-Crafts acylation reactions using carboxylic acids, acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions.

ORTHO METALATION DIRECTED BY α-AMINO ALKOXIDES. AN IMPROVED SYNTHESIS OF ORTHO-SUBSTITUTED ARYL KETONES

Ortho-substituted aryl ketones are prepared from N--N-methylbenzamides via ortho lithiation of intermediate α-amino alkoxides, formed in situ by addition of RLi.An ortho lithiation of N--N-methylbenzamide is also described.

Vinyl Cation Intermediates in Solvolytic and Electrophilic Reactions. 1. Solvolysis of α-Arylvinyl Derivatives

The solvolysis of 16 α-arylvinyl tosylates, bromides, and chlorides has been investigated in various alcohol-water mixtures and in acetic acid at several temperatures.All substrates were substituted with either 2-methyl or 2,6-dimethyl groups to accelerate the rates of reaction.The major or exclusive product isolated in most cases was the acetophenone arising from hydrolysis of the expected enol ethers or acetates during workup.The kinetics were simple first order in the vast majority of cases, with excess base added to prevent side reactions.Leaving group effects, Winstein-Grunwald m values, Schleyer Q values, and effects of solvent nucleophilicity all point to a limiting SN1 ionization generating a vinyl cation intermediate, in which there is little rear-side nucleophilic assistance by solvent.Substituent effects led to ρ values in the range -3.9 to -5.3 vs. ?+.Activation parameters are typical for an SN1 process, and ΔS% is insensitive to the presence of zero, one, or two o-methyl groups, as are the effects of solvent polarity on the rates.The results should therefore be directly comparable with other solvolytic or electrophilic reactions generating formally similar vinyl cation intermediates.