3717-39-3 Usage
General Description
N-methyladamantan-1-amine, also known as memantine, is a chemical compound that belongs to the class of medications known as NMDA receptor antagonists. It is commonly used in the treatment of Alzheimer's disease and other forms of dementia. Memantine works by blocking the activity of certain receptors in the brain that are involved in learning and memory processes, thereby helping to regulate the excessive activity of these receptors that can lead to the symptoms of dementia. This medication is thought to improve cognitive function and slow the progression of the disease, making it a valuable option for individuals suffering from neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 3717-39-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,1 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3717-39:
(6*3)+(5*7)+(4*1)+(3*7)+(2*3)+(1*9)=93
93 % 10 = 3
So 3717-39-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H19N.ClH/c1-12-11-5-8-2-9(6-11)4-10(3-8)7-11;/h8-10,12H,2-7H2,1H3;1H
3717-39-3Relevant articles and documents
Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources
Chakrabarti, Kaushik,Mishra, Anju,Panja, Dibyajyoti,Paul, Bhaskar,Kundu, Sabuj
supporting information, p. 3339 - 3345 (2018/07/29)
A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation.
