N-methyladamantan-1-amine hydrochloride

Base Information

• Chemical Name: N-methyladamantan-1-amine hydrochloride
• CAS No.: 3717-39-3
• Molecular Formula: C11H20ClN
• Molecular Weight: 201.739
• Hs Code.: 2921300090
• Mol file: 3717-39-3.mol

Synonyms:N-methyladamantan-1-amine hydrochloride;3717-39-3;N-methyladamantan-1-amine;hydrochloride;1-(N-Methylamine)adamantanamine hydrochloride;NSC 187507;1-ADAMANTANAMINE, N-METHYL-, HYDROCHLORIDE;N(C)C12CC3CC(C1)CC(C2)C3;SCHEMBL3027024;AKOS024302080;adamantan-1-yl-methylamine hydrochloride;FT-0695189;N-methyl-N-(1-adamantyl)amine hydrochloride

Chemical Property of N-methyladamantan-1-amine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0804mmHg at 25°C
• Melting Point: 250-251 °C
• Boiling Point: 226.8°C at 760 mmHg
• Flash Point: 84°C
• PSA: 12.03000
• LogP: 2.56550
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 201.1284273
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

99% ^*data from raw suppliers

MC004129:Adamantan-1-yl-methyl-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC12CC3CC(C1)CC(C3)C2.Cl

Technology Process of N-methyladamantan-1-amine hydrochloride

There total 5 articles about N-methyladamantan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(1-adamantyl)formamide (3405-48-9) → (1-adamantyl)(methyl)amine hydrochloride (3717-39-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 40 ℃; for 5h;

DOI:10.1016/S0968-0896(00)00072-9

Reference yield: 66.0%

methanol (67-56-1) + 1-Azidoadamantane (24886-73-5) → (1-adamantyl)dimethylamine (3717-40-6) + (1-adamantyl)(methyl)amine hydrochloride (3717-39-3)

Guidance literature:

methanol; 1-Azidoadamantane; With trans-RuCl(phenpyra-Me)(PPh₃)₂PF₆; sodium hydroxide; at 125 ℃; for 24h; Sealed tube; Inert atmosphere; Glovebox;

With hydrogenchloride;

DOI:10.1039/c8gc00863a

Reference yield: 35.0%

methanol (67-56-1) + 1-Azidoadamantane (24886-73-5) → (1-adamantyl)dimethylamine (3717-40-6) + 1-Adamantanamine (768-94-5) + (1-adamantyl)(methyl)amine hydrochloride (3717-39-3)

Guidance literature:

methanol; 1-Azidoadamantane; With trans-RuCl(phenpyra-Me)(PPh₃)₂PF₆; sodium hydroxide; at 125 ℃; for 5h; Sealed tube; Inert atmosphere; Glovebox;

With hydrogenchloride;

DOI:10.1039/c8gc00863a

upstream raw materials:

N-(1-adamantyl)formamide

1-Adamantanamine

methanol

1-Azidoadamantane