3736-22-9Relevant academic research and scientific papers
A facile total synthesis of ent-17β-estradiol and structurally related analogues
Cai, Zu Yun,Covey, Douglas F.
, p. 351 - 359 (2008/02/04)
A facile six-step synthesis (15.2% yield) of ent-17β-estradiol from readily accessible precursors is described. The preparation of analogues with 2-alkyl substituents, double bond unsaturation in the C-ring, a cis C,D-ring fusion and modified substituents at C17 is also reported.
A Total Synthesis of Estradiol and its 6,6-Dimethyl Analogue
Collins, Mark A.,Jones, D. Neville
, p. 4467 - 4470 (2007/10/02)
A short, stereoselective synthesis of estradiol, and its 6,6-dimethyl analogue, was accomplished from non-steroidal starting materials.A key feature was the use of a benzothiophene unit to effect (i) the stereoselective formation of the required 8β-H c
