3739-82-0

Basic information

• Product Name: Pyrimidine, 2-ethoxy- (7CI,8CI,9CI)
• Synonyms: Pyrimidine, 2-ethoxy- (7CI,8CI,9CI);2-Ethoxypyrimidine
• CAS NO: 3739-82-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14052
• Product Categories: PYRIMIDINE
• Mol File: 3739-82-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 2-ethoxy- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-ethoxy- (7CI,8CI,9CI)(3739-82-0)
• EPA Substance Registry System: Pyrimidine, 2-ethoxy- (7CI,8CI,9CI)(3739-82-0)

Safety Data

• Hazardous Substances Data: 3739-82-0(Hazardous Substances Data)

Upstream product

• 45695-56-5 pyrimidine-2-carboxamidine 
• 64-17-5 ethanol 
• 15718-46-4 2,2'-dipyrimidyl disulfide 
• 14080-23-0 2-cyanopyrimidine 
• 141-52-6 sodium ethanolate 
• 4595-60-2 2-bromopyrimidine 
• 1722-12-9 2-chloropyrimidine 
• 1450-85-7 2-thioxopyrimidine 

Downstream Products

• 557-01-7 Pyrimidin-2(1H)-one 

Relevant articles and documents

Cs2CO3-Promoted C?O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere

In this work, a Cs2CO3-promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C?O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C?O cross-coupling reactions.

Decyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines

The transition metal-free cross-coupling reactions of cyanopyrimidines with aliphatic alcohols, thiols (or S-alkylisothiourea salts) and amines, giving the corresponding alkoxylpyrimidines, aminopyrimidines, and alkylthiopyrimidines, are reported. Prelimi

Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles under focused microwave irradiation

Rapid nucleophilic displacement reactions of 2-chloropyrimidine, 2-bromopyrimidine, 5-bromopyrimidine and chloropyrazine with nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to the classical heating processes.