374629-49-9

Upstream product

• 16439-95-5 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 50-01-1 guanidine hydrochloride 
• 66752-03-2 3-bromo-2-oxo-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepine 

Relevant academic research and scientific papers

Hetaryl-1,5 Benzodiazepines—Part I: Synthesis of 3-pyrimidinyl- and Imidazolyl-1,5-benzodiazepines

Nucleophilic substitution of 3-bromo-4-phenyl-1H-[1,5]benzodiazepin-2-one (1) with thiourea or guanidine in presence of potassium carbonate afforded 1,5-benzodiazepin-3-ylimidothiocarbamate 2 or 1,5-benzodiazepin-3-ylguanidine 3, respectively. Pyrimidylthiobenzodiazepines 5, 6, 7, 8, 9, 10, 11, 12, 13 were obtained via the reaction of compound 2 with malononitrile dimer, diethyl malonate, methylenemalononitriles, or a mixture of an aldehyde and β-keto esters or acetylacetone, catalyzed using ceric ammonium nitrate. Reaction of compound 2 or 3 with α-halo esters, nitriles, and/or ketones afforded imidazoles 14, 15, 16, 17, 18, 19, 20, respectively.

Synthesis of new 3-substituted and spiro 1,5-benzodiazepin-2-ones under phase-transfer catalysis conditions

1,3-Dihydro-4-phenyl-1,5-benzodiazepin-2-one 1 was treated with bromine in 1:1 molar ratio to get the corresponding 3-bromo derivative 2 which in turn reacted with different nucleophiles to get the corresponding 3-substituted derivatives 3-11. The cyclize