3760-96-1Relevant academic research and scientific papers
KRAS G12C INHIBITORS
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Paragraph 0302-0303, (2019/05/24)
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
KRAS G12C INHIBITORS
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Paragraph 0183, (2017/12/18)
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25
Jain, Prashi,Flaherty, Patrick T.,Yi, Shuyan,Chopra, Ishveen,Bleasdell, Gwenyth,Lipay, Josh,Ferandin, Yoan,Meijer, Laurent,Madura, Jeffry D.
experimental part, p. 359 - 373 (2011/02/27)
Alzheimer's disease (AD) is a progressive neurodegenerative disease resulting in cognitive and behavioral impairment. The two classic pathological hallmarks of AD include extraneuronal deposition of amyloid β (Aβ) and intraneuronal formation of neurofibri
A NOVEL ROUTE TO 1-(N,N-DIMETHYLAMINO)-2-BUTANOL
Sard, Howard,Duffley, Richard P.,Razdan, Raj K.
, p. 813 - 816 (2007/10/02)
The title compound can be readily synthesized under mild conditions via addition of lithium dimethylamide to 1,2-epoxybutane.
Stereospecific Palladium-Promoted Oxyamination of Alkenes
Baeckvall, Jan E.,Bjoerkman, Eva E.
, p. 2893 - 2898 (2007/10/02)
A method for direct oxyamination of olefins to vicinal amino alcohol derivatives is described. The reaction proceeds via an aminopalladation-oxidation sequence.Terminal olefins give good yields (60-80percent) whereas internal olefins give lower yields (20-60percent).The oxyamination reaction is stereospecific as shown by reaction of (Z)- and (E)-2-butene and (E)-1-deuterio-1-decene and proceeds by overall cis stereochemistry.The stereochemical outcome is a result of a trans aminopalladation followed by an oxidative cleavage of the palladium carbon bond with inversion of configuration at carbon.Oxidation of the organopalladium ? complex to give an oxidized palladium intermediate, which could be a Pd(IV) intermediate, followed by SN2-type nucleophilic displacement of palladium is the most likely mechanism for the oxidative cleavage reaction.
