37613-36-8

Upstream product

• 5304-05-2 3-(4-fluorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 39833-45-9 3-(4-fluorophenyl)-1-phenylprop-2-yn-1-one 
• 100-63-0 phenylhydrazine 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 201230-82-2 carbon monoxide 
• 59-88-1 phenylhydrazine hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 352-06-7 1-(4-fluorobenzylidene)-2-phenylhydrazine 
• 70-11-1 α-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 399-10-0 4'-fluorochalcone 
• 591-50-4 iodobenzene 
• 144442-95-5 2,3-Dibromo-1-(4-fluoro-phenyl)-3-phenyl-propan-1-one 

Relevant academic research and scientific papers

Visible light mediated metal-free oxidative aromatization of 1,3,5-trisubstituted pyrazolines

The visible light mediated oxidation of 1,3,5-trisubstituted pyrazolines under metal-free conditions was developed. Various substituted pyrazolines were oxidized to pyrazoles by irradiation with visible light/sunlight. A plausible mechanism was proposed f

A Regioselective Approach to Trisubstituted Pyrazoles via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines

A palladium-catalyzed oxidative carbonylation of arylhydrazines and alkynes with balloon pressure CO/O2 to afford trisubstituted pyrazoles in a one-pot manner has been developed. The formation of trisubstituted pyrazoles involves a sequential C-N bond cleavage, carbonylation, Sonogashira coupling, Michael addition, and intramolecular condensation cyclization tandem process. An unprecedented oxidative Sonogashira-carbonylation reaction of arylhydrazine plays a key role for such a facile approach to pyrazoles.

Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the preparation of 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from α-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy under mild conditions with wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles.

Synthesis and anticancer activity of 1,3,5-triaryl-1H-pyrazole

Previous studies demonstrated that some pyrazole derivatives could be considered as potential anticancer agents. A series of 1,3,5-triaryl-1H-pyrazole derivatives were prepared by the reaction of phenylhydrazin and different chalcones. The previous classi

Regioselective Synthesis of 1,3,5-Substituted Pyrazoles from Acetylenic Ketones and Hydrazines

The synthesis of diversely substituted 1,3,5-substituted pyrazoles from the reaction of acetylenic ketones with substituted hydrazines is reported. The reactions were shown to be highly regioselective regardless of the nature of the substituents in the su

Synthesis and anti-inflammatory activity of fluorinated phenyl styryl ketones and N-phenyl-5-substituted aryl-3-p-(fluorophenyl) pyrazolins and pyrazoles

Various N-phenyl-5-substituted aryl-3-p-(fluorophenyl) pyrazolins and pyrazoles were synthesized by cyclization of the corresponding 4- (fluorophenyl) styryl and 4-(fluorophenyl) dibromostyryl ketones. These compounds were characterized by elemental analy