37932-45-9

Basic information

• Product Name: 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine
• Synonyms: [1,2,4,5]Tetrazine, 3,6-bis(4-chlorophenyl)-; 1,2,4,5-tetrazine, 3,6-bis(4-chlorophenyl)-
• CAS NO: 37932-45-9
• Molecular Formula: C₁₄H₈Cl₂N₄
• Molecular Weight: 303.1461
• Mol File: 37932-45-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 488.5°C at 760 mmHg
• Flash Point: 281.2°C
• Density: 1.398g/cm³
• Vapor Pressure: 3.25E-09mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine(37932-45-9)
• EPA Substance Registry System: 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine(37932-45-9)

Safety Data

• Hazardous Substances Data: 37932-45-9(Hazardous Substances Data)

Upstream product

• 53876-70-3 3,6-bis-(4-chloro-phenyl)-1,4-dihydro-[1,2,4,5]tetrazine 
• 623-03-0 4-Cyanochlorobenzene 
• 140-29-4 phenylacetonitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 140-53-4 p-chlorobenzyl cyanide 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 104-88-1 4-chlorobenzaldehyde 
• 3335-29-3 (4-chlorophenyl)(piperidin-1-yl)methanethione 
• 16687-61-9 5-(4-chlorophenyl)-1H-tetrazole 
• 53876-70-3 3,6-bis(4-chlorophenyl)-1,2-dihydro-1,2,4,5-tetrazine 
• 439579-45-0 5-(4-chlorophenyl)-2-trityltetrazole 

Downstream Products

• 1303541-48-1 6-chloro-8-(4-chlorophenyl)-3,3-dimethyl-1-phenyl-3,3a-dihydroindeno[2,1-b]pyrrol-2-one 
• 1303541-55-0 3,6a-bis(4-chlorophenyl)-6,6-dimethyl-4-phenyl-6,6a-dihydropyrrolo[3,2-c]pyrazol-5-one 
• 132380-57-5 C₂₉H₂₁Cl₂N₃ 
• 53876-70-3 3,6-bis-(4-chloro-phenyl)-1,4-dihydro-[1,2,4,5]tetrazine 
• 87521-59-3 3,6-bis(4-chlorophenyl)-4-methylpyridazine 
• 95309-28-7 3,6-bis(4-chlorophenyl)-1,4-dihydro-1-methyl-s-tetrazine 

Relevant articles and documents

Novel synthesis of 3,6-disubstituted-1,2,4,5-tetrazine derivatives from hydrazones by using [hydroxyl(tosyloxy)iodo]benzene

A mild and efficient protocol for the construction of 1,4-dihydro-3,6- disubstituted-1,4-bis(p-toluenesulfonyl)-1,2,4,5-tetrazines from p-toluenesulfonyl hydrazones mediated by [hydroxyl(tosyloxy)iodo]benzene in the presence of pyridine has been developed. This protocol affords the products in good to excellent yields. The corresponding 3,6-disubstituted-1,2,4,5-tetrazines can be easily obtained through one-step N-deprotection of p-toluensulfonyl groups and aromatization by tetrabutyl ammonium fluoride in THF. A mechanism has been proposed.

Diazocinones: Synthesis and conformational analysis

1,2,4,5-Tetrazines (prepared from aryl nitriles) condense with isoxazolylcyclobutanones (prepared from 3-benzenesulfonyl-3-vinylcyclobutanol) in methanolic KOH to give conformationally restricted 6-isoxazol-5-yl-6,7- dihydro-5H-[1,2]diazocin-4-ones. The s

Synthesis and antitumor activity of s-tetrazine derivatives

Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.