37974-23-5

Upstream product

• 685892-30-2 3-bromo-3-methyl-heptan-4-one 
• 124-41-4 sodium methylate 
• 60-29-7 diethyl ether 
• 67-56-1 methanol 
• 142-82-5 n-heptane 
• 201230-82-2 carbon monoxide 
• 15726-15-5 3-methyl-4-heptanone 
• 868-57-5 methyl 2-methylbutanoate 
• 107-08-4 1-iodo-propane 

Downstream Products

• 5343-52-2 2-methyl-2-ethylpentanoic acid 
• 1541196-70-6 C₂₅H₃₀N₂O 

Relevant academic research and scientific papers

First examples of the selective carbonylation of C6-C10 linear alkanes to tertiary carbonyl-containing compounds

The carbonylation of C6-C10 n-alkanes with CO in the presence of CBr4·2A1Br3 at -40°C and 1 atm CO leads to the products of non-destructive carbonylation, i.e., the esters of tertiary carboxylic acids, R1/

Nickel-catalyzed site-selective alkylation of unactivated C(sp 3)-H bonds

The direct alkylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp3 C-H bonds of methyl groups via a five-membered ring intermediate over the sp2 C-H bonds of arenes in the cyclometalation step.

Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)-H bonds

The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp3 C-H bond functionalization process. The reaction favors predominantly the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds. Moreover, a preference for activating sp3 C-H bonds of β-methyl groups, via a five-membered ring intermediate, over the aromatic sp2 C-H bonds was also observed in the cyclometalation step. Additionally, sp3 C-H bonds of unactivated secondary sp3 C-H bonds could be functionalized by favoring the ring carbon atoms over the linear carbon atoms. Getting ahead on tams: The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp 3 C-H bond functionalization process to deliver β-lactams. The reaction favors the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds, as well as aromatic C(sp2)-H bonds and unactivated secondary C(sp3)-H bonds of rings.