38053-75-7

Upstream product

• 7787-82-8 Trichloro-(1-chloro-ethyl)-silane 
• 71-43-2 benzene 
• 100-42-5 styrene 
• 7446-70-0 aluminium trichloride 
• 7440-05-3 palladium 
• 10025-78-2 trichlorosilane 
• 75-79-6 Methyltrichlorosilane 

Downstream Products

• 18292-20-1 β-phenethylsilane 
• 1445-91-6 (S)-1-phenylethanol 
• 1517-69-7 (R)-1-phenylethanol 
• 98-85-1 rel-(R)-1-phenethanol 
• 60-12-8 2-phenylethanol 
• 17961-78-3 α-methylbenzyl(trimethyl)silane 
• 98-85-1 1-Phenylethanol 

Relevant academic research and scientific papers

Homogeneous Palladium-Catalyzed Selective Reduction of 2,2′-Biphenols Using HCO 2H as Hydrogen Source

An efficient homogeneous palladium-catalyzed selective deoxygenation of 2,2′-biphenols by reduction of aryl triflates with HCO 2H as the hydrogen source is reported. This protocol complements the current method based on heterogeneous Pd/C-catalyzed hydrogenation with hydrogen gas. This process provided the reduction products in good to excellent yields, which could be readily converted to various synthetically useful molecules, especially ligands for catalytic synthesis.

Asymmetric Synthesis of Axially Chiral 2-Aminobiaryls by Rhodium-Catalyzed Benzannulation of 1-Arylalkynes with 2-(Cyanomethyl)phenylboronates

Asymmetric benzannulation of 1-arylalkynes, where the aryl group is an ortho-substituted aromatic group, with 2-(cyanomethyl)phenylboronate was catalyzed by a rhodium complex coordinated with a chiral diene ligand to give high yields of axially chiral 2-aminobiaryls with greater than 90 % ee.

METALLATED BENZYLSILANES AND THEIR USE AS POLYMERIZATION INITIATORS

The invention relates to novel compounds useful as polymerization initiators or precursors for polymerization initiators. The invention further relates to a method of making the polymerization initiators and resulting polymers. The invention also relates

The design of second generation MOP-phosphonites: Efficient chiral hydrosilylation of functionalised styrenes

A series of enantiopure MOP-phosphonite ligands, with tailored steric profiles, have been synthesised and are proven to be very successful in high-yielding, regio- and enantioselective catalytic hydrosilylation reactions of substituted styrenes, affording important chiral secondary alcohols.

When Chirality Meets “Buchwald-Type” Phosphines: Synthesis and Evaluation in Frustrated Lewis Pair-, Lewis Base- and Palladium-Promoted Asymmetric Catalysis

We describe the synthesis of axially chiral “Buchwald ligand”-like biphenylphosphines in highly enantioenriched form. These monodentate phosphines, biphenyl analogues of Hayashi's MOP ligands, were evaluated in phosphine-promoted organocatalysis and in hydrosilylations catalyzed by palladium or by frustrated Lewis pairs. As expected, the title phosphines appeared best suited for transition metal catalysis where they provided higher asymmetric induction.

Asymmetric Suzuki-Miyaura cross-coupling for the synthesis of chiral biaryl compounds as potential monophosphine ligands

Efficient asymmetric Suzuki-Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to >95:5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.

ACTIVATED HALO-CONTAINING ARALKYLSILANE

The invention is directed to an activated halo-containing aralkylsilanes possessing at least one hydrolyzable group bonded to a silicon atom and at least one halo functional group bonded to a carbon atom to which both the silicon atom and an aromatic grou

Air-stable chiral primary phosphines: A gateway to MOP ligands with previously inaccessible stereoelectronic profiles

The air-stable chiral primary phosphines 1a,b facilitate the synthesis of previously inaccessible or hard-to-access chiral MOP-type ligands 2a,b-5a,b, which can be prepared in one-pot reactions. These derivatives have been prepared to allow for a unique comparison of their differing structural and electronic profiles, determined here by a number of experimental and theoretical studies. Phosphiranes 2a,b and phosphonites 5a,b are electron-poor compounds, with the former possessing exceptional thermal stability. Conversely, the dimethylarylphosphines 3a,b and bis(dimethylamino)arylphosphines 4a,b are good electron donors, and, in contrast to earlier reports, the dialkylarylphosphines were found to be remarkably air-stable. The ligands were coordinated to platinum(II), and the weak trans-influence of the highly strained phosphiranes 2a,b was revealed both in solution and in the solid state. The steric parameters of the ligands were investigated by the allyl rotation of their methallylpalladium(II) complexes, which showed subtle differences in exchange rates. Aryl side-on coordination of the MOP-backbone to palladium(II) was observed for complexes with a non-coordinating counterion and structurally analyzed in the case of ligand 4b. The asymmetric induction and catalytic activity of 2a,b-5a,b were tested in the hydrosilylation of styrene as well as the allylic alkylation of (rac)-(E)-1,3-diphenylallyl acetate. Major differences in reactivity were related back to the electronic parameters of the ligands.