38114-34-0Relevant academic research and scientific papers
Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents
Mizutani, Yusuke,Tanimoto, Hiroki,Morimoto, Tsumoru,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi
supporting information, p. 5903 - 5906,4 (2020/08/20)
Double nucleophilic N-alkylation of α-oxime-esters, affording N,N-dialkyl-α-amino acids is herein described. Grignard reagents accomplished double N-alkylations via umpolung and various N,N-dialkylated α-amino acids were successfully synthesized in 15 min. Both electron-withdrawing sulfonyl groups and electron-donating silyl and methyl groups on oximes were available. Alkylmagnesium species and (E)-configuration of α-oxime-ester were essential to this cascade reaction.
Oxime derivatives and the use thereof as photoinitiators
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, (2008/06/13)
Radically photopolymerizable compositions comprising (a) at least one ethylenically unsaturated photopolymerizable compound; (b) as photoinitiator, at least one compound of the formula I, II, III and/or IV wherein m is 0 or 1; n is 0, 1, 2 or 3; x is 1 or 2; R1 is inter alia phenyl, naphthyl, anthracyl or phenanthryl, a heteroaryl radical, C2-C12alkenyl, C4-C8cycloalkenyl, or C6-C12bicycloalkenyl; R'1 is inter alia C2-C12alkylene, or phenylene; R2 has one of the meanings of R1 or inter alia is phenyl; y is 1 or 2; R3 if x is 1 inter alia is C1-C18alkylsulfonyl, or phenyl-C1-C3alkylsulfonyl, R3 if x is 2, is for example C2-C12alkylenedisulfonyl; R4 and R5 inter alia are hydrogen, halogen, or C1-C8alkyl; A is for example -S-, -O-, or -NR10-; R10 inter alia is hydrogen, or phenyl; and (c) at least one coinitiator; are especially suitable for the preparation of colour filter systems.
Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
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, (2008/06/13)
This invention provides a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance.
Preparation and mechanism of solvolysis of N-hydroxy-α- oxobenzeneethanimidoyl chloride, a 2-(hydroxyimino)-1-phenylethan-1-one derivative: Molecular structure of α-oxo-oximes (=α-(hydroxyimino) ketones)
Hamersak, Zdenko,Peric, Berislav,Kojic-Prodic, Biserka,Cotarca, Livius,Delogu, Pietro,Sunjic, Vitomir
, p. 1289 - 1301 (2007/10/03)
Acid-catalyzed methanolysis of N-hydroxy-α-oxobenzeneethanimidoyl chloride (1), a 2-(hydroxyimino)-1-phenylethan-1-one derivative obtained in one step from acetophenone, leads to a constant ratio of methyl α- oxobenzeneacetate (2) and methyl α-(hydroxyimino)benzeneacetate (3). 13C(α) Labelled [13C]-1 affords 13C(α) labelled [13C]-3, thus discarding the hypothesis of its formation via 1,2-arene migration. The reported sequence opens a novel approach to phenylglyoxylic and mandelic acid esters (=α-oxobenzeneacetic and α-hydroxybenzeneacetic acid esters), from acetophenone. The molecular structures of 1 and 3 were determined by X-ray structure analysis and compared with previously reported crystallographic data of α-oxo-oximes (=α-(hydroxyimino) ketones) 4 and 6-8. The unique stereoelectronic characteristics of the α-oxo-oxime moiety are discussed. All α-oxo-oximes share the following structural characteristics: (E)- configuration of the oxime C=N-OH bond (i.e. OH and C=O trans), the s-trans conformation of the oxo and imino moieties about the C(α)-C(=NOH) single bond, and intermolecular H-bonding. They differ from the isostructural α- diketone enols by the absence of resonance-assisted intramolecular H-bonding.
Novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl) oxybenzoic acid ester derivatives, processes for their production an a method for their application as herbicides
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, (2008/06/13)
The present invention relates to novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid iminoester derivative of the general formula(I); processes for their preparation and a method for their application as herbicides: Therein, Q represents a straight or branched alkyl, alkenyl or cycloalkyl group having from 1 to 10 carbon atoms, preferably from 1 to 8 carbon atoms, which may be substituted with a (C1-C4)alkoxy or (C1-C4)alkylthio group; a (C1-C4)alkyl or (C2-C4)alkenylthio group; a phenylthio group; a phenyl(C1-C4)alkyl or phenyl(C2-C4)alkenylthio group; or a radical of the following formula: [wherein R1 and R2 are same or different each other and represent hydrogen or a halogen atom; or a group selected from the groups which comprised with a (C1-C4)alkyl, a (C2-C4)alkenyl, an acyl, an acyloxy, a (C1-C4)alkylthio, a nitro, a cyano, a phenyl and a phenoxy group, and which, if necessary, may be substituted with a halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy or an acetal group; or R1 and R2 may constitute an acetal structure with carbon atoms to which R1 and R2 are linked.; and, n is 0 or 1.]; or a 5-6 membered ring system containing one or more hetero atoms such as oxygen, sulfur or nitrogen atom in the ring system, which may have one or more proper substituents such as a halogen atom, a (C1-C4)alkyl, a hydroxy, a nitro or a cyano group on its certain positions.; and, R represents a hydrogen or a halogen atom, a cyano group, or -Z -R3 [wherein, R3 represents a (C1-C4)alkyl, an alkoxy or alkenyloxyl group having from 1 to 8 carbon atoms, or a phenyl, a phenoxy or an amino group, or 5-6 membered hetero or aromatic ring system connecting to Z through out a (C1-C2)alkyl or alkoxy bridge, such as a phenyl, a furyl, a thienyl, pyrrolyl or pyranyl group, and which may have one or more proper substituents such as a halogen atom, a (C1-C4)alkyl, a hydroxy, a nitro or a cyano group on its certain positions, or R3 may be cyclized with Z and Q in some cases.; and, Z represents -O-, -S-, [wherein, R4 is a hydrogen atom, a (C1-C4)alkyl or a phenyl group, or constitutes a cyclic system containing an oxygen atom with R3]].
