38114-34-0Relevant articles and documents
Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents
Mizutani, Yusuke,Tanimoto, Hiroki,Morimoto, Tsumoru,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi
supporting information, p. 5903 - 5906,4 (2020/08/20)
Double nucleophilic N-alkylation of α-oxime-esters, affording N,N-dialkyl-α-amino acids is herein described. Grignard reagents accomplished double N-alkylations via umpolung and various N,N-dialkylated α-amino acids were successfully synthesized in 15 min. Both electron-withdrawing sulfonyl groups and electron-donating silyl and methyl groups on oximes were available. Alkylmagnesium species and (E)-configuration of α-oxime-ester were essential to this cascade reaction.
Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
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, (2008/06/13)
This invention provides a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance.
Novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl) oxybenzoic acid ester derivatives, processes for their production an a method for their application as herbicides
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, (2008/06/13)
The present invention relates to novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid iminoester derivative of the general formula(I); processes for their preparation and a method for their application as herbicides: Therein, Q represents a straight or branched alkyl, alkenyl or cycloalkyl group having from 1 to 10 carbon atoms, preferably from 1 to 8 carbon atoms, which may be substituted with a (C1-C4)alkoxy or (C1-C4)alkylthio group; a (C1-C4)alkyl or (C2-C4)alkenylthio group; a phenylthio group; a phenyl(C1-C4)alkyl or phenyl(C2-C4)alkenylthio group; or a radical of the following formula: [wherein R1 and R2 are same or different each other and represent hydrogen or a halogen atom; or a group selected from the groups which comprised with a (C1-C4)alkyl, a (C2-C4)alkenyl, an acyl, an acyloxy, a (C1-C4)alkylthio, a nitro, a cyano, a phenyl and a phenoxy group, and which, if necessary, may be substituted with a halogen atom, a (C1-C4)alkyl, a (C1-C4)alkoxy or an acetal group; or R1 and R2 may constitute an acetal structure with carbon atoms to which R1 and R2 are linked.; and, n is 0 or 1.]; or a 5-6 membered ring system containing one or more hetero atoms such as oxygen, sulfur or nitrogen atom in the ring system, which may have one or more proper substituents such as a halogen atom, a (C1-C4)alkyl, a hydroxy, a nitro or a cyano group on its certain positions.; and, R represents a hydrogen or a halogen atom, a cyano group, or -Z -R3 [wherein, R3 represents a (C1-C4)alkyl, an alkoxy or alkenyloxyl group having from 1 to 8 carbon atoms, or a phenyl, a phenoxy or an amino group, or 5-6 membered hetero or aromatic ring system connecting to Z through out a (C1-C2)alkyl or alkoxy bridge, such as a phenyl, a furyl, a thienyl, pyrrolyl or pyranyl group, and which may have one or more proper substituents such as a halogen atom, a (C1-C4)alkyl, a hydroxy, a nitro or a cyano group on its certain positions, or R3 may be cyclized with Z and Q in some cases.; and, Z represents -O-, -S-, [wherein, R4 is a hydrogen atom, a (C1-C4)alkyl or a phenyl group, or constitutes a cyclic system containing an oxygen atom with R3]].
