38202-09-4Relevant academic research and scientific papers
BF3-Etherate-Promoted Cascade Reaction of 2-Alkynylanilines with Nitriles: One-Pot Assembly of 4-Amido-Cinnolines
Senadi, Gopal Chandru,Gore, Babasaheb Sopan,Hu, Wan-Ping,Wang, Jeh-Jeng
, p. 2890 - 2893 (2016)
A BF3-etherate-promoted cascade reaction of nitriles with 2-alkynylanilines is described. This method achieves the formation of two new C-N bonds through a reaction sequence of diazotization with t-BuONO, nucleophilic addition of the alkyne to
Metal Free Access to Polysubstituted Pyrimidines via Nitrile Activation and [2+2+2] Cycloaddition
Chai, Jinkui,Nie, Yu,Wang, Zhao,Cheng, Li,Liu, Ying-Guo,Wu, Junliang
supporting information, p. 17565 - 17569 (2021/10/25)
Tf2O mediated intermolecular / intramolecular [2+2+2] cycloaddition between alkynes and nitriles has been developed for efficient construction of polysubstituted pyrimidines and bicyclopyrimidines. In presence of Tf2O, aza-allene species were generated in situ through nitrile activation and subsequently participated in the [2+2+2] cycloaddition, which was fully supported by deuteration experiments. The reaction had good substrate extensibility with moderate to excellent yield including trimethylsilylalkynes. The method was utilized as a synthetic tool in the preparation of a luminescent metal complex.
Cycloaddition of 1,4-diaryl-1,3-butadiynes with nitriles: An atom-economic one-pot approach to benzo[f]quinazolines
Yang, Lichen,Hua, Ruimao
supporting information, p. 769 - 771 (2013/07/26)
A one-pot synthesis of benzo[ f]quinazoline by a novel cycloaddition of 1,4-diaryl-1,3-butadiynes with nitriles in the presence of trifluoromethanesulfonic acid at 120 °C is developed.
Studies on Pyrimidine Derivatives. XLI.1) Palladium-Catalyzed Cross-Coupling Reaction of Halopyrimidines with Aryl- and Vinyltributylstannanes
Kondo, Yoshinori,Watanabe, Ry,Sakamoto, Takao,Yamanaka, Hiroshi
, p. 2814 - 2816 (2007/10/02)
The arylation of 2-, 4-, and 5-halopyrimidines with aryltributylstannanes in the presence of dichlorobis(triphenylphosphine)palladium was investigated with successful results.The reaction can be expanded to the synthesi of 2-, 4-, and 5-vinylpyrimidines w
A SIMPLE DIRECT APPROACH TO 1-SUBSTITUTED 3-ARYLISOQUINOLINES FROM DEOXYBENZOINS AND NITRILES
Garcia, Alberto,Lete, Esther,Villa, M. Jesus,Dominguez, Esther,Badia, M. Dolores
, p. 6681 - 6686 (2007/10/02)
A new one-pot synthesis of 3-arylisoquinolines was accomplished by reaction of deoxybenzoins with an excess of nitriles and phosphorus pentoxide at room temperature.The usefulness of this synthesis was demonstrated by the facile preparation of 1-alkyl, 1-
