38210-84-3

Usage

InChI:InChI=1/C12H14O5/c1-7(13)9-6-11(17-3)10(16-2)4-8(9)5-12(14)15/h4,6H,5H2,1-3H3,(H,14,15)

Upstream product

• 90149-75-0 ethyl 2-acetyl-4,5-dimethoxyphenylacetate 
• 17173-27-2 methyl 2-(2-acetyl-4,5-dimethoxyphenyl)acetate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 64-19-7 acetic acid 
• 59077-27-9 N-[2-(2-Acetyl-4,5-dimethoxy-phenyl)-acetyl]-acetamide 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 

Downstream Products

• 3809-00-5 4,5-dimethoxyhomophthalic acid 
• 134307-27-0 12,12-Diacetyl-4,5-dimethoxy-8,11-dimethyl-9-oxa-tricyclo[6.2.2.0^2,7]dodeca-2⁽⁷⁾,3,5-trien-10-one 
• 142272-79-5 6,7-Dimethoxy-1-methyl-3-(toluene-4-sulfonyl)-isoquinoline 
• 144709-15-9 [4,5-Dimethoxy-2-(1-oxo-1,2-dihydro-isoquinolin-3-yl)-phenyl]-acetic acid 
• 144709-21-7 [2-(6,7-Dimethoxy-1-oxo-1,2-dihydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-acetic acid 
• 144709-33-1 [2-(7,8-Dimethoxy-1-oxo-1,2-dihydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-acetic acid 
• 170711-01-0 (3S,10bR)-8,9-Dimethoxy-10b-methyl-3-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 134307-23-6 C₂₂H₁₉NO₆ 
• 132234-11-8 2-Acetyl-4,5-dimethoxybenzaldehyde 
• 144709-31-9 3<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-1,7,8-trimethoxyisoquinoline 
• 144709-24-0 N-methyl-3<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 144709-22-8 3-<2-(methoxycarbonyl-methyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 144709-30-8 N-methyl-3-<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-7,8-dimethoxy-1(2H)-isoquinolone 
• 144709-28-4 3-<2-(methoxycarbonylmethyl)-4,5 dimethoxyphenyl>-7,8-dimethoxy-1(2H)-isoquinolone 

Relevant academic research and scientific papers

Synthesis of isoquinolines from 2-phenylethylamines, amides, nitriles and carboxylic acids in polyphosphoric acid

A convenient one pot synthesis of 1-, 1.3-substituted 3,4-dihydroisoquinolines 5 enamines 10 and 3-oxo-2,3-dihydroisoquinolines 18 as well as of enamides 22 of isoquinoline from 2-phenyl-, 1,2-diphenylethylamines, phenylacetamides, phenylacetonitriles, N-acylphenylethylamines and carboxylic acids in nonaqueous media has been accomplished.

A common and general access to berberine and benzo [c] phenanthridine alkaloids

The S(RN)1 reactions between o-iodobenzamides and the enolate anion from 2-acetyl homoveratric acid lead to key tricyclic compounds which are easily converted to either berberine or benzo [c] phenanthridine ring systems providing thus a highly-yielding and versatile access to both classes of alkaloids.