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38609-97-1 Usage


9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.

Check Digit Verification of cas no

The CAS Registry Mumber 38609-97-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,6,0 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38609-97:
151 % 10 = 1
So 38609-97-1 is a valid CAS Registry Number.

38609-97-1 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (O0432)  9-Oxoacridine-10-acetic Acid  >98.0%(HPLC)(T)

  • 38609-97-1

  • 1g

  • 395.00CNY

  • Detail
  • TCI America

  • (O0432)  9-Oxoacridine-10-acetic Acid  >98.0%(HPLC)(T)

  • 38609-97-1

  • 5g

  • 1,290.00CNY

  • Detail
  • Sigma

  • (17927)  9-Oxo-10(9H)-acridineacetic acid  for HPLC derivatization, ≥99.0% (T)

  • 38609-97-1

  • 17927-250MG

  • 2,109.51CNY

  • Detail

38609-97-1Relevant articles and documents

Development of a HPLC-FL method to determine benzaldehyde after derivatization with: N -acetylhydrazine acridone and its application for determination of semicarbazide-sensitive amine oxidase activity in human serum

Dong, Xiuli,Tang, Jiayuan,Ren, Yan,Chen, Xiangming

, p. 6717 - 6723 (2019)

A novel fluorescence labeling reagent N-acetylhydrazine acridone (AHAD) was designed and synthesized. A highly sensitive high performance liquid chromatography (HPLC) method coupled with fluorescence detection to determine benzaldehyde after derivatization with AHAD was developed. Optimum derivatization was obtained at 40 °C for 30 min with trichloroacetic acid as catalyst. Benzaldehyde derivative was separated on a reversed-phase SB-C18 column in conjunction with a gradient elution and detected by fluorescence detection at excitation and emission wavelengths of 371 nm and 421 nm. The established method exhibited excellent linearity over the injected amount of benzaldehyde of 0.003 to 5 nmol mL-1. The method was successfully applied to the determination of serum semicarbazide-sensitive amine oxidase (SSAO) activity in humans. SSAO is a significant biomarker because serum SSAO activity is elevated in patients with Alzheimer's disease, vascular disorders, heart disease and diabetes mellitus. It was demonstrated that the SSAO activity of the hyperglycemic group (60 ± 4 nmol mL-1 h-1) was significantly higher than that of normal blood sugar group (44 ± 4 nmol mL-1 h-1) with P 0.05.

Method for synthesizing oxo-10-acridineacetic acid by adopting phase-transfer catalysis method


Paragraph 0030; 0044; 0045; 0047; 0050; 0051; 0072, (2018/09/14)

The invention discloses a method for synthesizing oxo-10-acridineacetic acid by adopting a phase-transfer catalysis method. The method comprises the following steps of 1, preparing acridone, wherein diphenylamine and an acid catalyst are dissolved into an organic solvent, the mixture reacts with CO2 under the pressure of 0.6-0.7 MPa, pressure relief is performed, water is added, stirring is performed, filtering is performed, standing and layering are performed, an organic phase is sampled for washing, the solvent is evaporated out, and drying is performed to obtain the acridone; 2, preparing oxo-10-acridineacetic acid, wherein the acridone, chloroacetic acid and the phase transfer catalyst are added into a mixed solvent containing DMF and NaOH for a reaction under the temperature of 80-100DEG C, TLC is adopted for monitoring the complete reaction, the reaction is stopped, cooling is performed till room temperature is reached, ice water is added to obtain solid precipitates, the precipitates are filtered and washed to obtain a wet product midbody, the wet product midbody is added into a NaOH water solution, stirring is performed under the room temperature for dissolution, filteringis performed, the NaOH water solution is use for cleaning the filtered solid, washing solutions are mixed, the pH value is adjusted to be 4-5, solid precipitates are obtained, and filtering, washingand drying are performed to obtain the oxo-10-acridineacetic acid.

A quinacridone N - alkylated derivatives of preparation method


Paragraph 0016; 0017; 0018, (2017/08/02)

The invention discloses a preparation method of acridone N-alkylation derivative, which comprises the following steps: adding an alkaline ion liquid and acridone into a three-neck flask provided with a condensation reflux unit at room temperature, stirring uniformly, adding halide, stirring to react at 20-50 DEG C for 6-12 hours, standing at room temperature, filtering, washing the filter cake with methanol, and drying to obtain the acridone N-alkylation derivative product. The method has the advantages of mild reaction conditions, high yield and recyclable ion liquid, is safe and convenient to operate, and has favorable industrialized application value.

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