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5H-dibenzo[c,e]azepine-5,7(6H)-dione is a chemical compound with the molecular formula C12H7NO2. It is a tricyclic aromatic compound, featuring a dibenzazepine core structure with two carbonyl groups at positions 5 and 7. 5H-dibenzo[c,e]azepine-5,7(6H)-dione is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals, particularly as a precursor in the production of certain drugs. Its chemical properties and reactivity make it a valuable intermediate in organic synthesis, although specific applications and safety considerations should be carefully evaluated.

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  • 3864-08-2 Structure
  • Basic information

    1. Product Name: 5H-dibenzo[c,e]azepine-5,7(6H)-dione
    2. Synonyms:
    3. CAS NO:3864-08-2
    4. Molecular Formula: C14H9NO2
    5. Molecular Weight: 223.2268
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3864-08-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 460.8°C at 760 mmHg
    3. Flash Point: 201.7°C
    4. Appearance: N/A
    5. Density: 1.291g/cm3
    6. Vapor Pressure: 1.13E-08mmHg at 25°C
    7. Refractive Index: 1.636
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 5H-dibenzo[c,e]azepine-5,7(6H)-dione(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5H-dibenzo[c,e]azepine-5,7(6H)-dione(3864-08-2)
    12. EPA Substance Registry System: 5H-dibenzo[c,e]azepine-5,7(6H)-dione(3864-08-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3864-08-2(Hazardous Substances Data)

3864-08-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3864-08-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,6 and 4 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3864-08:
(6*3)+(5*8)+(4*6)+(3*4)+(2*0)+(1*8)=102
102 % 10 = 2
So 3864-08-2 is a valid CAS Registry Number.

3864-08-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name benzo[d][2]benzazepine-5,7-dione

1.2 Other means of identification

Product number -
Other names dibenzo[c,e]azepine-5,7-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3864-08-2 SDS

3864-08-2Relevant articles and documents

Hypolipidemic activity of phthalimide derivatives V: Reduced and hydrolytic products of simple cyclic imides

Chapman Jr.,Wyrick,Josee Voorstad,et al.

, p. 1482 - 1484 (1984)

A series of cyclic imides and related compounds have previously been shown to possess hypolipidemic activity at the low dose level of 20 mg/kg/d. Hydrolytic and reduced products of the cyclic imides were synthesized and examined to discern if possible metabolic products were the active chemical species of these hypolipidemic agents. Phthalimide proved to be the most active cyclic imide tested. Unfortunately, the new products did not, in general, improve hypolipidemic activity in rodents. The exceptions were piperidine which demonstrated improved hypotriglyceridemic activity, and 3,4,5,6-dibenzohomopiperidin-2-one, which demonstrated improved hypocholesterolemic activity compared to phthalimide.

Synthesis of 5H-Dibenzo[c,e]azepine-5,7(6H)-diones from Benzamides via Palladium-Catalyzed Double C-H Bond Activation

Kondapalli, Vijayakumar,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming

, p. 2288 - 2293 (2017)

A convenient and efficient method for the synthesis of 5H-dibenzo[c,e]azepine-5,7(6H)-diones from simple and readily available benzamides is described in this work. The palladium-catalyzed homocoupling of benzamides occurred via ortho-selective double C-H bond activation using the simplest amide CONH2 as a directing group. The subsequent intramolecular condensation reaction proceeded smoothly to produce 5H-dibenzo[c,e]azepine-5,7(6H)-diones in satisfactory to excellent yields in one pot.

Preparation method of dibenzo [c, e] aza-5, 7 (6H)-dione compound

-

Paragraph 0032-0034, (2017/07/22)

The invention belongs to the field of medical and chemical intermediates and related chemical technology, and relates to a preparation method of a dibenzo [c, e] aza-5, 7 (6H)-dione compound. The dibenzo [c, e] aza-5, 7 (6H)-dioneis an important bioactive molecule, has a skeleton structure frequently appearing in a pharmaceutical molecule, has better effects on reducing blood fat, treating obesity, resisting epinephrine and the like, can be significantly applied in the fields such as organic synthesis and pharmaceutical chemistry, and has a wide market prospect. According to the preparation method of the dibenzo [c, e] aza-5, 7 (6H)-dione compound provided by the invention, benzamide is adopted as a raw material, and a series of dibenzo [c, e] aza-5, 7 (6H)-dikone and a derivative thereof are synthesized under the action of a palladium catalyst. The method has the advantages of short synthetic route, simplicity in operation, higher yield and the like. The preparation method of the dibenzo [c, e] aza-5, 7 (6H)-dione compound provided by the invention has a larger use value and social and economic benefits.

A facile synthesis of 6-alkyl-6,7-dihydro-5H-dibenz[c,e]azepines: Potent hypolipidemics

Akula,Kabalka

, p. 3901 - 3906 (2007/10/03)

6-Alkyl-6,7-dihydro-5H-dibenz[c,e]azepines were synthesized in two steps in 63-88% overall yield by utilizing an efficient borane-tetrahydrofuran reduction of imides.

Photochemical Electron-transfer Reactions of Biphenyl-2,2'-dicarboximide and Naphthalene-1,8-dicarboximide with Olefin. Dependence of the Reaction Course on the Structure of the Aromatic Imide

Kubo, Yasuo,Araki, Takeo,Maruyama, Kazuhiro

, p. 2863 - 2869 (2007/10/02)

Photoreactions of N-methylbiphenyl-2,2'-dicarboximide and N-ethylnaphthalene-1,8-dicarboximide (2) with 1,1-diphenylethylene (3) in methanol gave methanol-incorporated 1:1:1-adduct (7) and 2,2-diphenylethyl methyl ether (6), an anti-Markovnikov adduct of methanol to 3.The ratio of the two types of products largely depends on the structure of the aromatic imides.Probably the spin densities of the radical anions of the aromatic imides seem to play an important role to determine the reaction courses after the photochemical electron-transfer process.Similar results were obtained in the photoreaction of N-(2-phenylallyl)aromatic imides; elimination induced by methanol-incorporation vs. anti-Markovnikov addition of methanol. Photoreactions of N-(trans-3-phenylallyl) aromatic imides in methanol gave methanol-incorporated O-cyclized products (20 and 27) and C-cyclized products (21 and 28).A tentative mechanism for the O-cyclization is proposed; i.e., intramolecular electron transfer followed by anti-Markovnikov addition of methanol to the radical cation of the double bond moiety, nucleophilic attack of the aromatic imide radical anion moiety, secondary electron-transfer, and then polar addition of methanol.

Comparison of the hypolipidemic activity of cyclic vs. acyclic imides

Voorstad,Chapman,Cocolas,Wyrick,Hall

, p. 9 - 12 (2007/10/02)

Two series of nitrogen-substituted cyclic and acyclic imides were examined for hypolipidemic activity in mice after dosing for 16 days at a dose of 20 mg/kg per day. The hypolipidemic activity of the unsubstituted, N-butyl, N-3-oxobutyl, and N-2-carboxyethyl derivatives of diacetimide and succinimide were compared as well as the unsubstituted and N-substituted dibenzimide and diphenimide. It was shown that an imide functionally incorporated into a ring was not necessary for hypocholesterolemic activity. Good hypocholesterolemic activity was observed in both series of acyclic and cyclic imides. However, a cyclic imido structure was a necessary requirement for good hypotriglyceridemic activity. A decrease in hypotriglyceridemic activity was noted when comparing the cyclic imides to their respective acyclic congeners.

Hypolipidemic activity of N-substituted diphenimides in rodents

Murthy,Wyrick,Voorstad,Hall

, p. 547 - 550 (2007/10/02)

A number of N-substituted diphenimide derivatives were investigated for hypolipidemic activity in mice at 20 mg/kg/day I.P. A number of the compounds were found to be more active than clofibrate and equally as active as other cyclic imides reported previously in the literature. N-(4-Methylphenyl)-diphenimide demonstrated the most potent acitivity lowering serum cholesterol levels by 48% and serum triglyceride levels by 40% after 16 days administration of drug.

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