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5-Fluoro-8-hydroxyquinoline, a derivative of quinoline with the molecular formula C9H6FNO, is a chemical compound characterized by the presence of a fluorine atom at the 5-position and a hydroxyl group at the 8-position. It is known for its potential pharmaceutical applications, antimicrobial and antifungal properties, and its ability to chelate metal ions, making it a versatile compound in various fields.

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  • 387-97-3 Structure
  • Basic information

    1. Product Name: 5-FLUORO-8-HYDROXYQUINOLINE
    2. Synonyms: 5-FLUOROOXINE;5-FLUORO-8-HYDROXYQUINOLINE;5-FLUORO-8-QUINOLINOL;5-Fluoro-8-Quinolinol98%;5-Fluoro-8-hydroxyquinoline 99%;5-Fluoro-8-hydroxyquinoline99%;5-FLUORO-8-QUINOLINOL 99+%
    3. CAS NO:387-97-3
    4. Molecular Formula: C9H6FNO
    5. Molecular Weight: 163.15
    6. EINECS: 223-418-7
    7. Product Categories: Quinoline&Isoquinoline;Haloquinolines;Hydroxyquinolines;Quinolines
    8. Mol File: 387-97-3.mol
  • Chemical Properties

    1. Melting Point: 110 °C
    2. Boiling Point: 330.8 °C at 760 mmHg
    3. Flash Point: 153.9 °C
    4. Appearance: /
    5. Density: 1.366 g/cm3
    6. Vapor Pressure: 0.151mmHg at 25°C
    7. Refractive Index: 1.451
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: soluble in Ether,Ethanol,Acetone
    10. CAS DataBase Reference: 5-FLUORO-8-HYDROXYQUINOLINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-FLUORO-8-HYDROXYQUINOLINE(387-97-3)
    12. EPA Substance Registry System: 5-FLUORO-8-HYDROXYQUINOLINE(387-97-3)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 387-97-3(Hazardous Substances Data)

387-97-3 Usage

Uses

Used in Coordination Chemistry:
5-Fluoro-8-hydroxyquinoline is used as a ligand for metal ions, playing a crucial role in coordination chemistry. Its ability to form stable complexes with metal ions contributes to the development of new materials and compounds.
Used in Pharmaceutical Applications:
5-Fluoro-8-hydroxyquinoline is studied for its potential pharmaceutical applications, including its antimicrobial and antifungal properties. It has been investigated as a potential antitumor agent, offering a promising avenue for the development of new therapeutic agents.
Used in Analytical Chemistry:
5-FLUORO-8-HYDROXYQUINOLINE's ability to chelate metal ions makes it useful in analytical chemistry. It can be employed in the detection and quantification of metal ions, as well as in the development of new analytical methods and techniques.
Used in Material Development:
5-Fluoro-8-hydroxyquinoline's metal-chelating properties also make it a potential component in the development of new materials. Its coordination with metal ions can lead to the creation of novel materials with unique properties and applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 387-97-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 387-97:
(5*3)+(4*8)+(3*7)+(2*9)+(1*7)=93
93 % 10 = 3
So 387-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H2F8/c13-3-1-4(14)10(18)7(9(3)17)8-11(19)5(15)2-6(16)12(8)20/h1-2H

387-97-3 Well-known Company Product Price

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  • TCI America

  • (F0038)  5-Fluoro-8-quinolinol  >99.0%(GC)(T)

  • 387-97-3

  • 1g

  • 1,980.00CNY

  • Detail
  • TCI America

  • (F0038)  5-Fluoro-8-quinolinol  >99.0%(GC)(T)

  • 387-97-3

  • 5g

  • 5,900.00CNY

  • Detail

387-97-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Fluoro-8-quinolinol

1.2 Other means of identification

Product number -
Other names 5-fluoroquinolin-8-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:387-97-3 SDS

387-97-3Relevant articles and documents

Quinoline synthesis by improved Skraup-Doebner-Von Miller reactions utilizing acrolein diethyl acetal

Ramann, Ginelle A.,Cowen, Bryan J.

supporting information, p. 6436 - 6439 (2015/11/16)

A robust synthetic method has been developed as an improvement to the venerable Skraup-Doebner-Von Miller reaction providing access to various quinoline products. The straightforward procedure utilizes acrolein diethyl acetal as a three-carbon annulation partner with aniline substrates in a monophasic, organic solvent-free reaction medium. Differentially substituted aniline precursors were found to be compatible with the reaction conditions and the corresponding quinoline products are isolated in moderate to good yields.

Fluorinated Alq3 derivatives with tunable optical properties

Shi, Yue-Wen,Shi, Min-Min,Huang, Jia-Chi,Chen, Hong-Zheng,Wang, Mang,Liu, Xiao-Dong,Ma, Yu-Guang,Xu, Hai,Yang, Bing

, p. 1941 - 1943 (2008/03/13)

This communication reports that not only the emission colour but also the photoluminescence quantum yield of Alq3 can be tuned by introducing fluorine atoms at different positions; with fluorination at C-5 the emission is red-shifted with a tremendously decreased intensity, fluorination at C-6 causes a blue-shift with a significantly increased intensity, and fluorination at C-7 has a minor effect on both the colour and intensity of Alq3's emission. The Royal Society of Chemistry 2006.

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