38806-09-6

Basic information

• Product Name: METHYL 1-ACETYLCYCLOPROPYLCARBOXYLATE
• Synonyms: METHYL 1-ACETYLCYCLOPROPYLCARBOXYLATE;Methyl 1-acetylcyclopropanecarboxylate;1-ACETYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER;methyl 1-acetylcyclopropane-1-carboxylate;methyl 1-(1-oxoethyl)cyclopropanecarboxylate;Cyclopropanecarboxylic acid, 1-acetyl-, methyl ester
• CAS NO: 38806-09-6
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.16
• EINECS: 200-589-5
• Product Categories: CMLLYL
• Mol File: 38806-09-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 183.638°C at 760 mmHg
• Flash Point: 68.57°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.763mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: METHYL 1-ACETYLCYCLOPROPYLCARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-ACETYLCYCLOPROPYLCARBOXYLATE(38806-09-6)
• EPA Substance Registry System: METHYL 1-ACETYLCYCLOPROPYLCARBOXYLATE(38806-09-6)

Safety Data

• Hazardous Substances Data: 38806-09-6(Hazardous Substances Data)

Usage

Uses

1-Acetylcyclopropanecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of vitamin D carboxylates as immunosuppressants, antihyperproliferatives, and vitamin D-active agents.

InChI:InChI=1/C7H10O3/c1-5(8)7(3-4-7)6(9)10-2/h3-4H2,1-2H3

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 105-34-0 methyl 2-cyanoacetate 
• 109-77-3 malononitrile 
• 108-59-8 malonic acid dimethyl ester 
• 107-06-2 1,2-dichloro-ethane 
• 106-93-4 ethylene dibromide 
• 14668-82-7 vinyl isocyanide 

Downstream Products

• 156965-22-9 (5E,7E,22E)-(1S,3R)-1,3-Bis[[dimethyl(1,1dimethylethyl)silyl]oxy]-24-oxo-26,27-cyclo-9,10-secocholesta-5,7,10⁽¹⁹⁾,22-tetraene-25-carboxylic acid 
• 143878-86-8 (2S,3S)-<1-(1(S)-phenylethyl)-2-methylpyrrolidin-3-yl>carboxylic acid methyl ester 
• 143878-87-9 methyl (2S,3S)-2-methylpyrrolidine-3-carboxylate 
• 1426404-57-0 4-oxo-5-azabispiro[2.4]heptane-7-carboxylic acid {1-phenyl-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-yl}amide 
• 1426409-13-3 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid 
• 1426409-12-2 5-(2,4-dimethoxybenzyl)-4-oxo-5-azaspiro[2.4]heptane-7-carboxylic acid methyl ester 
• 1318756-83-0 1-acetyl-N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]cyclopropanecarboxamide 
• 56172-71-5 1-Acetylcyclopropane-1-carboxylic acid 
• 124572-92-5 1-(2-Methyl-1,3-dioxolan-2-yl)cyclopropanecarbaldehyde 

Relevant articles and documents

Synthesis method of 3,5-dihalogenated-2-pentanone

The invention discloses a synthetic method of 3,5-dihalogenated-2-pentanone, and belongs to the technical field of organic chemistry. According to the method, acetoacetate is taken as a raw material,and cyclopropanation, ring-opening halogenation and hydrolysis decarboxylation reactions are carried out successively so as to obtain 3,5-dihalogenated-2-pentanone. The method has the advantages of simple and accessible raw materials, high atom utilization ratio in the halogenation step and fewer wastes. The reaction conditions of all steps are simple, purification is not needed in the process, continuous feeding can be achieved, cyclic application of the cyclopropanation catalyst can be achieved, and potential industrial amplification prospects are achieved.

CYANOPYRROLIDINES AS USP30 INHIBITORS AND FIBROSIS TREATMENT

The present invention relates to novel treatments of fibrotic diseases, including, inter alia, fibrosis of the lung, liver and kidney, and to substituted-cyanopyrrolidines of formula (I) having activity as inhibitors of ubiquitin specific peptidase 30 (US

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.