3884-31-9

Basic information

• Product Name: 4-Phenyl-2(3H)-thiazolone
• Synonyms: SALOR-INT L499528-1EA;BUTTPARK 16\06-68;2-HYDROXY-4-PHENYLTHIAZOLE;4-PHENYLTHIAZOL-2-OL;4-PHENYL-2(3H)-THIAZOLONE;4-Phenyl-1,3-thiazol-2-ol;4-Phenyl-2-thiazolol;4-phenylthiazol-2(3H)-one
• CAS NO: 3884-31-9
• Molecular Formula: C₉H₇NOS
• Molecular Weight: 177.22
• EINECS: 200-589-5
• Mol File: 3884-31-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 207-210°C
• Boiling Point: 385 °C at 760 mmHg
• Flash Point: 186.7 °C
• Appearance: /
• Density: 1.301 g/cm³
• Vapor Pressure: 1.77E-06mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 4-Phenyl-2(3H)-thiazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-2(3H)-thiazolone(3884-31-9)
• EPA Substance Registry System: 4-Phenyl-2(3H)-thiazolone(3884-31-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 3884-31-9(Hazardous Substances Data)

Usage

General Description

4-Phenyl-2(3H)-thiazolone is a chemical compound with a thiazolone ring structure and a phenyl group attached to it. It is a heterocyclic compound that is used in organic synthesis and medicinal chemistry. It has been studied for its potential pharmacological properties, including anti-inflammatory and anticancer activities. Additionally, 4-Phenyl-2(3H)-thiazolone has been investigated for its potential use as a building block in the synthesis of various biologically active compounds. Its unique structure and potential pharmaceutical applications make it an interesting target for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C9H7NOS/c11-9-10-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H,10,11)

Upstream product

• 64-19-7 acetic acid 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 79307-55-4 2-methoxy-4-phenylthiazole 
• 536-74-3 phenylacetylene 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 333-20-0 potassium thioacyanate 
• 98-86-2 acetophenone 
• 625-57-0 O-ethyl thiocarbamate 

Downstream Products

• 54199-76-7 3-methyl-4-phenylthiazol-2(3H)-one 
• 79307-55-4 2-methoxy-4-phenylthiazole 
• 1826-23-9 2-chloro-4-phenylthiazole 
• 127719-30-6 C₃₅H₃₆N₂O₈S₂ 
• 127719-29-3 C₃₃H₃₂N₂O₇S₂ 
• 109758-20-5 3-(3-ciclopropil)-4-fenil-3H-tiazol-2-one 
• 120590-09-2 2-<(4-phenyl-2-thiazolyl)oxy>propionic acid ethyl ester 
• 120590-10-5 2-<2-oxo-4-phenyl-3(2H)-thiazolyl>propionic acid ethyl ester 
• 20061-75-0 6-ethoxy-3-methyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzothiazolium; iodide 
• 22584-68-5 4,6-dibromo-1,3-dimethyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzoimidazolium; iodide 
• 21337-67-7 5-bromo-1,3-dimethyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzoimidazolium; iodide 
• 21337-66-6 5-chloro-1,3-dimethyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzoimidazolium; iodide 
• 21337-65-5 1,3,5-trimethyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzoimidazolium; iodide 
• 21337-68-8 5-methoxy-1,3-dimethyl-2-[(2-oxo-4-phenyl-2H-thiazol-5-ylidene)-hydrazino]-benzoimidazolium; iodide 

Relevant articles and documents

Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

A regioselective visible light induced synthesis of aryl α-thiocyano ketones/thiocyano alcohols from activated terminal aryl alkynes and aryl 1,3-conjugated dienes was achieved. This mild and non-metallic oxidation is exclusively driven by benign ambient air in the presence of an organic photo-catalyst and NH4SCN. This protocol was also demonstrated at the 5 mmol scale for the synthesis of potentially therapeutic 2-hydroxy 4-substituted arylthiazoles in good yields, signifying its amenability for large-scale application.

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright

CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1

This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih); (Ii); (Ij), (Ik), (II) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.