3885-46-9

Basic information

• Product Name: 2-Quinoxalinecarboxylic acid, 3-phenyl-, ethyl ester
• CAS NO: 3885-46-9
• Molecular Formula: C17H14N2O2
• Molecular Weight: 278.31
• Mol File: 3885-46-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-Quinoxalinecarboxylic acid, 3-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinoxalinecarboxylic acid, 3-phenyl-, ethyl ester(3885-46-9)
• EPA Substance Registry System: 2-Quinoxalinecarboxylic acid, 3-phenyl-, ethyl ester(3885-46-9)

Safety Data

• Hazardous Substances Data: 3885-46-9(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 221171-91-1 ethyl 2-bromo-3-phenyl-2H-azirine-2-carboxylate 
• 25015-52-5 ethyl 2-cyano-3-phenyloxirane-2-carboxylate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 53256-22-7 ethyl β-anilinocinnamate 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 62-53-3 aniline 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 3556-76-1 ethyl (2Z)-3-phenyl-3-(phenylamino)prop-2-enoate 
• 81447-37-2 ethyl 3-oxo-3-phenyl-2-(tosyloxy)propanoate 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 
• 124716-83-2 Ethyl 2-<<(p-nitrophenyl)sulfonyl>oxy>-2-benzoylacetate 
• 57859-60-6 ethyl 3-phenylquinoxaline-2-carboxylate 1,4-di-N-oxide 
• 191152-69-9 3-Chloro-2-cyano-2-hydroxy-3-phenyl-propionic acid ethyl ester 

Downstream Products

• 1504-78-5 3-phenylquinoxaline-2(1H)-one 
• 22239-98-1 1-(3-phenylquinoxalin-2-yl)ethan-1-one 
• 5021-43-2 2-phenylquinoxaline 
• 6954-91-2 11H-Indeno[1,2-b]quinoxaline-11-one 
• 1133716-36-5 3-phenylquinoxaline-2-carbohydrazide 
• 92427-66-2 3-phenylquinoxaline-2-carboxylic acid 

Relevant articles and documents

Reactivity of 2-Halo-2H-azirines. 1. Reactions with Nucleophiles

Nucleophilic substitution reactions of 2-halo-2H-azirines 1a, 1b, 1d, and 1e with potassium phthalimide and aniline allowed the preparation of new substituted 2H-azirines 2-5. The reactions of 2-bromo-2H-azirine 1a with methylamine led to the synthesis of

Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C?H Bond Amination of N-Aryl Enamines

An efficient and metal-free double C?H bond amination of N-aryl enamines using isobutyl nitrite (IBN) has been developed. This method enables the preparation of functionalized quinoxalines in good to excellent yields and tolerates a variety of N-aryl enamines with diverse functional substituents. Mechanistic studies revealed the presence of a key β-imino oxime ester intermediate. A quinoxaline derivative could be prepared from β-carbonyl ester in one-pot sequence on a gram scale. Finally, two important quinoxaline scaffolds were easily prepared in moderate yields over two steps. (Figure presented.).

PIFA-promoted intramolecular oxidative C(aryl)-H amidation reaction: Synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones

A facile and direct intramolecular oxidative C(aryl)-H amidation reaction was developed for the synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones in moderate to excellent yields starting from readily available materials by tethering the adjacent N-methoxyamide and aryl portions in the presence of phenyliodine(III) bis(trifluoroacetate) at room temperature. This metal-free approach is a valuable addition to the traditional methods already available for the preparation of these molecules.