3899-32-9

Upstream product

• 42933-31-3 Ethyl 3,6,7-trimethyl-2,6-octadienoate 
• 58307-67-8 3,6,7-trimethyl-6-octen-1-en-3-ol 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 408328-44-9 3,6,7-trimethyl-6-octen-1-en-3-yl acetate 
• 127-08-2 potassium acetate 
• 67-64-1 acetone 
• 127348-54-3 6-phenylsulfonyl-3,6,7-trimethylocta-2E,7-dien-1-ol 
• 130627-71-3 6-benzoylsulfonyl-3,7-dimethylocta-2E,7-dien-1-yl acetate 
• 131534-46-8 2-acetyl-4,5-dimethyl-hex-4-enoic acid ethyl ester 
• 5072-70-8 1-bromo-2,3-dimethyl-2-butene 
• 19310-95-3 2,3-dimethylbut-2-en-1-ol 
• 13979-28-7 ethyl 2,3-dimethylbut-2-enoate 

Downstream Products

• 645-68-1 pseudoirone 
• 91212-46-3 α-methylcyclogeraniol 
• 72074-86-3 (+-)-4t-(2,5t,6,6-Tetramethyl-cyclohex-2-en-r-yl)-but-3-en-2-on 
• 79-69-6 (+/-)-α-Iron 
• 72074-85-2 (+-)-4t-(2,5c,6,6-tetramethyl-cyclohex-2-en-r-yl)-but-3-en-2-one 
• 18445-02-8 (E)-6,9,10-trimethylundeca-5,9-dien-2-one 
• 35906-92-4 (+/-)-α-methylcyclocitral 
• 72074-84-1 beta-irone 
• 31162-52-4 2,5,6,6-tetramethylcyclohex-1-enecarbaldehyde 

Relevant academic research and scientific papers

Rerouting and Improving Dauc-8-en-11-ol Synthase from Streptomyces venezuelae to a High Yielding Biocatalyst

The dauc-8-en-11-ol synthase from Streptomyces venezuelae was investigated for its catalytic activity towards alternative terpene precursors, specifically designed to enable new cyclisation pathways. Exchange of aromatic amino acid residues at the enzyme surface by site-directed mutagenesis led to a 4-fold increase of the yield in preparative scale incubations, which likely results from an increased enzyme stability instead of improved enzyme kinetics.

SELECTIVE HYDROGENATION OF ALDEHYDE WITH RU/BIDENTATE LIGANDS COMPLEXES

The present invention relates to processes for the reduction by hydrogenation, using molecular H2, of a C5-C20 substrate containing one or two aldehydes functional groups into the corresponding alcohol or diol, characterized in that said process is carried out in the presence of —at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the N2P2O2, wherein the coordinating atoms N2 are provided by a first bidentate ligand, the coordinating atoms P2 are provided by a second bidentate ligand and the coordinating atoms O2 are provided by two non-linear carboxylate ligands; and —optionally of an acidic additive.

Synthesis of teleocidins A, B and their congeners. Part 3. Synthesis of dihydroteleocidin B-4 (dihydroteleocidin B), teleocidin B-3 and teleocidin B-4

Details of the synthesis method of the tumor promoters teleocidin B-3 (3), teleocidin B-4 (4) and dihydroteleocidin B-4 (9) (=dihydroteleocidin B) from (S)- and (R)-methyl N-methyl-N-[7-(3,6,7-trimethyl-1,6-octadien-3-yl)-4-indolyl]-L-valinates (20b and 20a) are presented.

TOTAL SYNTHESES OF (+/-)-β-IRONE

The conversion of the product of the ene reaction of PhSOCl with geranyl acetate into racemic β-irone has been accomplished in seven steps, using high-pressure techniques for the olefination of β-methylcyclocitral.