39050-26-5Relevant articles and documents
Interaction between novel porphyrin-dextran nanoparticles and human serum albumin
Zhang, Zhi,Guo, Qian-Ni,Lu, Yun-Guo,Jia, Tao,Yan, Kun,Li, Zao-Ying
, p. 264 - 270 (2010)
A novel porphyrin-dextran coated Fe3O4 nanoparticle (5) was designed and synthesized. The structure of 5 was confirmed by IR, UV-vis and inductively coupled plasma atomic emission spectrometry, and dynamic laser scattering (DLS); magnetic property was measured by a vibrating sample magnetometer (VSM). The interaction between compound 5 and human serum albumin (HSA) was investigated through UV-vis absorbance spectra and fluorospectrophotometer, compared with the 5-(4-aminophenyl)-10,15,20-tris-(4- sulfonatophenyl)porphyrin, trisodium salt (3). The results showed compound 5 containing porphyrin moiety and 3 could interact with HSA. The quenching constant (Ksv) was 4.739 × 105 M-1 for 3, and 2.846 × 105 M-1 for 5; the apparent affinity binding constant (KA) was 8.562 × 103 M-1 for 3, and 4.978 × 104 M-1 for 5.
Harnessing nature's insights: Synthetic small molecules with peroxidase-mimicking DNAzyme properties
Stefan, Loic,Xu, Hai-Jun,Gros, Claude P.,Denat, Franck,Monchaud, David
, p. 10857 - 10862 (2011)
Substitute features: The demonstration that small DNAs can acquire enzymatic properties (DNAzyme activity) is appealing since it makes protein-based biotechnologies simpler. Herein, two further simplifications of this process are proposed: the substitution of DNAs for small molecules, called DOTA-templated synthetic G-quartets (DOTASQ), and of hemin for the more practically convenient iron(III) porphyrin (FeTPPS; see scheme). Copyright
Photodegradation of Rhodamine B using Aqueous Free-Base Porphyrin and Metalloporphyrins of Divalent Metal Ions
Gokakakar, S. D.,Salker, A. V.
, p. 147 - 154 (2022/01/06)
The present study is focused on the photodegradation of rhodamine B using aqueous free-base photocatalysts in presence of solar radiation. All catalysts such as free-base tetrasodium meso-tetra(p-sulphonatophenyl)porphyrin (TPPS4) or abbreviated as TPS and substituting M = Co, Ni, Cu, Zn and Ag into the moiety of TPS to get metalloporphyrins, were synthesized. Further, they were characterized by UV-visible, IR and 1H MMR spectroscopic techniques. The photodegradation of rhodamine B of concentration 10-5 M was carried out with 5 mg of a photocatalyst of free-base and other metalloporphyrins. It was observed that these synthesized photocatalysts have shown the photodegradation efficiency to the extent of 100% within time period of 5 to 40 min. The process of degradation was verified with HPLC and ion-chromatography.
Conformational-Switch Based Strategy Triggered by [18] π Heteroannulenes toward Reduction of Alpha Synuclein Oligomer Toxicity
Chakraborty, Ritobrita,Sahoo, Sumit,Halder, Nyancy,Rath, Harapriya,Chattopadhyay, Krishnananda
, p. 573 - 587 (2018/10/31)
A water-soluble meso-carboxy aryl substituted [18] heteroannulene (porphyrin) and its Zn-complex have been found to be viable in targeting α-Syn aggregation at all its key microevents, namely, primary nucleation, fibril elongation, and secondary nucleation, by converting the highly heterogeneous and cytotoxic aggresome into a homogeneous population of minimally toxic off-pathway oligomers, that remained unexplored until recently. With the EC50 and dissociation constants in the low micromolar range, these heteroannulenes induce a switch in the secondary structure of toxic prefibrillar on-pathway oligomers of α-Syn, converting them into minimally toxic nonseeding off-pathway oligomers. The inhibition of the aggregation and the reduction of toxicity have been studied in vitro as well as inside neuroblastoma cells.
