39140-45-9Relevant academic research and scientific papers
A Simple and Unambiguous Synthesis of α,α- and α,α'-Dihalogeno Ketones
Barluenga, Jose,Llavona, Lujan,Concellon, Jose M.,Yus, Miguel
, p. 297 - 300 (2007/10/02)
A convenient method for the unambiguous preparation of α,α'-dihalogeno ketones 3 from in situ-generated chloromethyllithium and α-chloro or α-bromo carboxylic acid esters 1 at -78 deg C, is described.The unambiguous prparation of α,α-dihalogeno ketones 7 by using in situ-generated dihalogenomethyllithium and carboxylic acid esters 5 at -78 deg C is also reported.
PRODUCTION OF 1,1,1-TRIHALOGENO-2-ALKANOLS AND SOME OF THEIR PROPERTIES
Bal'on, Ya. G.,Shul'man, M. D.,Vakulenko, L. I.
, p. 1231 - 1237 (2007/10/02)
The reaction of acyclic and carbocyclic carbonyl compounds with haloforms was studied in liquid ammonia and dimethylformamide in the presence of basic catalysts (t-BuOK, KOH).As a result of the reaction 1,1,1-trihalogeno-2-alkanols were obtained.They were used for the synthesis of 1,1,1-trihalogeno-2-methoxyalkanes, 1,1-dibromoalkenes, 1,1-dichloro-2-methoxyalkenes, and alkyl mono- and dichloromethyl ketones.
Chlorination of Aliphatic Ketones in Methanol
Gallucci, R. R.,Going, R.
, p. 2532 - 2538 (2007/10/02)
The chlorination of aliphatic ketones in methanol has been examined.The product distributions in methanol differ substantially from those obtained by chlorination in carbon tetrachloride.The reaction in methanol favors addition of chlorine to the least substituted carbon α to the carbonyl group.The effect is especially pronounced if an α carbon bearing two substituents is present.The distribution of products is determined by the relative stability of the enol ethers formed from the ketone under the reaction conditions.
