21491-96-3Relevant academic research and scientific papers
PIPERAZINE SUBSTITUTED AZAPINE DERIVATIVES AND USES THEREOF
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Paragraph 0519, (2021/04/23)
The present disclosure relates to compounds of Formula (I) and (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating H1 and 5-HT2A receptors and are to be used in the treatment of sleep disorders, such as sleep fragmentation, disturbed sleep/arousals, and arousal threshold.
Atmospheric oxidation mechanism of methyl pivalate, (CH3)3CC(O)OCH3
Wallington,Ninomiya,Orkin,Carter,Mashino,Huie,Luo,Kawasaki,Kurylo,Malkina
, p. 7225 - 7235 (2007/10/03)
Smog chamber/FTIR techniques were used to study the Cl atom and OH radical initiated oxidation of methyl pivalate, (CH3)3CC(O)OCH3, in the presence of NOx in 700 torr of N2/O2 diluent at 296 K. The Cl atom initiated oxidation of methyl pivalate in the presence of 15-600 torr of O2 and 10-30 mtorr of NOx in 700 torr total pressure of N2 diluent at 296 K yielded HCHO, CO, acetone, CO2 and CH3OC(O)O2NO2. OH radical initiated oxidation of methyl pivalate in air produced acetone in a 51% yield. Flash photolysis-resonance fluorescence techniques were used to measure the rate constant for the reaction of OH radicals with methyl pivalate at 250-370 K. The rate constant showed a weak temperature dependence, increasing at both low and high temperature from a minimum value of about 1.2 × 10-12 cc/molecule-sec near room temperature. The data obtained were used to formulate a detailed mechanism describing the atmospheric oxidation of methyl pivalate. This mechanism gave predictions of the effects of methyl pivalate on O3 formation and other measures of reactivity that were in good agreement with results of environmental chamber experiments. It should be used in future airshed models to predict the effects of methyl pivalate emissions on air quality.
Synthesis of 1-amino-2,2-dialkylcyclopropanecarboxylic acids via base-induced cyclization of γ-chloro-α-imino ester
Boeykens,De Kimpe,Abbaspour Tehrani
, p. 6973 - 6985 (2007/10/02)
β-Chloro ketones were oxidatively transformed into α-keto carboxylic esters and condensed with primary amines in the presence of titanium(IV) chloride. Base-induced cyclization of the resulting γ-chloro-α-imino esters, incorporating suitable N-substituent
Preparation of 2,2-disubstituted 3-chloropropionic esters
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, (2008/06/13)
2,2-Disubstituted 3-chloropropionic esters I STR1 where R1 and R2 are each C1 -C6 -alkyl, C2 -C6 -oxaalkyl, C2 -C6 -alkenyl, C2 -C6 -oxaalkenyl,
Processes for producing herbicide intermediates
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, (2008/06/13)
Processes for producing 4,4-dimethyl-3-isoxazolidinone and intermediates for it from known and inexpensive starting materials are described and exemplified.
Chlorination of Carboxylic Acid Derivatives. VIII. Liquid Phase Chlorination of the Aliphatic C5-Carboxylic Acids and Their Chlorides, Methyl Esters and Chloromethyl Esters with Chlorine
Kornonen, Ilpo O. O.
, p. 467 - 474 (2007/10/02)
The chlorination of pentanoic, 3-methylbutanoic, 2-methylbutanoic and 2,2-dimethylpropanoic acids and their derivatives with chlorine in the liquid phase have been investigated.The monochloro products formed were determined by gas-liquid chromatography (GLC) and gas-liquid chromatography-mass spectrometry (GLC-MS) as their esters through the comparison with authentic samples.The deactivation of position 2 decreases in the order COCl > CO2H > CO2CH2Cl > CO2CH3, the effect of the COCl-group in pentanoic acid derivatives being 4.3 times stronger than that of the CO2CH3-group.The deactivation is smallest in 2-methylbutanoic acid derivatives owing to the electron-donating methyl group.The EI mass spectra of the methyl and chloromethyl esters have been studied in detail.
