21491-96-3

Basic information

• Product Name: 3-Chloro-2,2-dimethylpropionic acid methyl ester
• Synonyms: 3-Chloro-2,2-dimethylpropionic acid methyl ester
• CAS NO: 21491-96-3
• Molecular Formula: C₆H₁₁ClO₂
• Molecular Weight: 150.6
• Mol File: 21491-96-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 160.9°C at 760 mmHg
• Flash Point: 56°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 2.33mmHg at 25°C
• Refractive Index: 1.425
• CAS DataBase Reference: 3-Chloro-2,2-dimethylpropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2,2-dimethylpropionic acid methyl ester(21491-96-3)
• EPA Substance Registry System: 3-Chloro-2,2-dimethylpropionic acid methyl ester(21491-96-3)

Safety Data

• Hazardous Substances Data: 21491-96-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11ClO2/c1-6(2,4-7)5(8)9-3/h4H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 13511-38-1 3-chloropivalic acid 
• 57539-84-1 1,3-Dichloro-3-methyl-2-butanone 
• 124-41-4 sodium methylate 
• 39140-45-9 1,1-dichloro-3-methylbutan-2-one 
• 598-98-1 Methyl pivalate 
• 146679-15-4 1,1,4-trichloro-1-(phenylthio)-3,3,-dimethyl-2-butanone 
• 597-31-9 2,2-dimethyl-3-hydroxypropionaldehyde 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 1115-20-4 2,2-dimethyl-3-hydroxy-propyl 2,2-dimethyl-3-hydroxypropionate 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 81778-07-6 4,4-dimethyl-3-isoxazolidinone 

Relevant articles and documents

PIPERAZINE SUBSTITUTED AZAPINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) and (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating H1 and 5-HT2A receptors and are to be used in the treatment of sleep disorders, such as sleep fragmentation, disturbed sleep/arousals, and arousal threshold.

Synthesis of 1-amino-2,2-dialkylcyclopropanecarboxylic acids via base-induced cyclization of γ-chloro-α-imino ester

β-Chloro ketones were oxidatively transformed into α-keto carboxylic esters and condensed with primary amines in the presence of titanium(IV) chloride. Base-induced cyclization of the resulting γ-chloro-α-imino esters, incorporating suitable N-substituent

Processes for producing herbicide intermediates

Processes for producing 4,4-dimethyl-3-isoxazolidinone and intermediates for it from known and inexpensive starting materials are described and exemplified.