39149-82-1

Usage

Uses

Used in Organic Synthesis:
BENZENEPROPANOIC ACID, A-BROMO-, ETHYL ESTER is used as a synthetic intermediate for the production of various organic compounds. Its chemical structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BENZENEPROPANOIC ACID, A-BROMO-, ETHYL ESTER is used as a key component in the development of new drugs. Its unique structure can be modified to create novel molecules with potential therapeutic applications.
Used in Agrochemical Industry:
BENZENEPROPANOIC ACID, A-BROMO-, ETHYL ESTER is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its chemical properties make it a valuable starting material for the development of innovative products.
Used in Specialty Chemicals:
In the specialty chemicals sector, BENZENEPROPANOIC ACID, A-BROMO-, ETHYL ESTER is employed as a raw material for the production of various compounds with specific applications, such as dyes, fragrances, and additives for the plastics and coatings industries.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3107, 1949 DOI: 10.1021/ja01177a049

Upstream product

• 56-23-5 tetrachloromethane 
• 2985-39-9 2-benzylmalonic acid monoethyl ester 
• 7726-95-6 bromine 
• 64-17-5 ethanol 
• 16503-53-0 2-bromo-3-phenylpropanoic acid 
• 63-91-2 L-phenylalanine 
• 100-39-0 benzyl bromide 
• 109926-14-9 diethyl 2-bromo-2-benzylmalonate 
• 607-81-8 diethyl 2-benzylmalonate 
• 85969-93-3 potassium 2-benzyl-3-ethoxy-3-oxopropanoate 
• 100-44-7 benzyl chloride 
• 56409-75-7 ethyl 2-benzyl-3-oxo-3-phenylpropanoate 
• 150-30-1 Phenylalanine 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 16417-60-0 ethyl N-(trifluoroacetyl)-2-amino-3-phenylpropanoate 
• 4192-77-2 ethyl cinnamate 
• 138286-83-6 Ethyl N-(trichloroacetyl)-2-amino-3-phenylpropanoate 
• 324077-91-0 3-benzyl-3-(4-fluorobenzyl)imidazo[1,2-a]pyridin-2(3H)-one 
• 134676-49-6 3-(phenylmethyl)piperazinone 
• 1191098-82-4 ethyl 2-morpholino-3-phenylpropanoate 
• 1220703-72-9 ethyl 2-(4-methylpiperazin-1-yl)-3-phenylpropanoate 
• 1219705-60-8 (3-allylhexa-2,5-dienyl)benzene 
• 1372780-13-6 2,2-diallyl-3-benzyloxirane 
• 1514678-18-2 5-benzyl-2-phenylthiazol-4(5H)-one 

Relevant academic research and scientific papers

ANTIVIRAL COMPOUNDS

The present invention relates to novel compounds of general formula (I) wherein R1 to R4 and n have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.

Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Br?nsted base

An enantioselective intramolecular cyclization reaction of alkynyl esters was developed, which employs a Br?nsted base catalyst generated in situ from a chiral Schiff base and t-BuOK. This reaction is a rare example of the enantioselective intramolecular addition of simple ester enolates to alkynes under Br?nsted base catalysis.

Synthesis of heterocycles from arylation products of unsaturated compounds: XIII. 5-R1-benzyl-2-(R2-2-pyridylimino)thiazolidin-4-ones

Meerwein reactions of arenediazonium bromides with methyl and ethyl acrylates gave 3-aryl-2-bromopropionic acid esters which were subjected to cyclocondensation with N-(2-pyridyl)- and N-(6-methyl-2-pyridyl) thioureas to obtain 5-R1-benzyl-2-(R

One-pot synthesis of α-bromoesters and ketones from β-ketoesters and diketones using supported reagents system

A simple and efficient method has been developed for the synthesis of α-bromoesters and ketones from β-ketoesters and diketones in one pot using a supported reagents system, CuBr2/Al2O 3-Na2CO3/Al2O3, in which β-ketoester reacts first with CuBr2/Al2O3 and the product, α-bromo-β-ketoester, reacts with Na 2CO3/Al2O3 to give the final product, α-bromoesters in good yields.

Synthesis of optically pure (S)-2-acetylthio-3-benzenepropanoic acid via enzymatic resolution

A method of synthesizing optically pure (S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution.

Novel approaches to optically active substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones as conformationally constrained peptidomimetics

Synthesis of 4,5-dihydro-1,2,4-triazin-6-ones bearing different chiral α-amino acid residues at the C3 and N1 positions is reported. Cyclocondensation of N-thioacylphthalimides with α-amino hydrazides afforded C3 functionalised dihydrotriazinones in good

Synthesis of Heterocycles Based of the Products of Anionarylation of Unsaturated Compounds. II. * Method of Preparation of 2,5-Disubstituted 4-Thiazolidones

The products of haloarylation of acrylates by aryldiazonium salts (Meerwein reaction) react with thiourea and thiosemicarbazones forming thiazolidone cycle. The reaction is a convenient synthesis method of 5-benzylsubstituted 2-imino-4-thiazolidones and 2

A ONE-POT PREPARATION OF α-HALO-CARBONYL AND α-HALO-SULFONYL COMPOUNDS BY HALO-DEACYLATION

The reaction of β-ketoesters, β-diketones and β-sulfonylketones with N-halosuccinimides in the presence of a base gives α-halo-carbonyl and α-halo-sulfonyl derivatives by a one-pot halo-deacylation reaction.A facile synthesis of pseudo-ionone is described.

PREPARATION OF α-BROMOESTERS VIA THE HALF ESTERS OF MALONIC ACIDS A NOVEL METHOD FOR RAPID DECARBOXYLATION UNDER MILD CONDITIONS

α-Bromomalonic acid half esters were prepared in high yield and found to be rapidly decarboxylated to α-bromoesters under mild conditions using lithium carbonate in refluxing tetrahydrofuran.