3937-48-2

Usage

Uses

Used in Food and Beverage Industry:
(1α,4α)-1-Hydroxymethyl-4-methylcyclohexane is used as a flavoring agent for its distinctive peppermint taste and aroma, enhancing the sensory experience of various food and beverage products.
Used in Cosmetics Industry:
(1α,4α)-1-Hydroxymethyl-4-methylcyclohexane is used as a cooling agent in cosmetic products, providing a refreshing sensation and enhancing the overall user experience.
Used in Pharmaceutical Industry:
(1α,4α)-1-Hydroxymethyl-4-methylcyclohexane is used as an analgesic and anti-inflammatory agent in topical pain relief products, such as ointments and creams, to alleviate pain and inflammation.
Used in Oral Hygiene Products:
(1α,4α)-1-Hydroxymethyl-4-methylcyclohexane is used as a flavoring agent in oral hygiene products, imparting a fresh and cooling sensation to promote oral comfort and freshness.
Used in Respiratory Conditions Treatment:
(1α,4α)-1-Hydroxymethyl-4-methylcyclohexane is used as a cough suppressant and in the treatment of sore throat and respiratory conditions, providing relief and improving respiratory health.

Upstream product

• 39155-38-9 (4-methylcyclohex-3-en-1-yl)methanol 
• 2808-80-2 4-methyl-1-methylidenecyclohexane 
• 25244-23-9 cis-4-methyl-1-(ethoxycarbonyl)cyclohexane 
• 6493-79-4 methyl 4-methyl-3-cyclohexene-1-carboxylate 
• 99-94-5 p-Toluic acid 
• 934-67-8 (cis)-4-methylcyclohexanecarboxylic acid 
• 20292-15-3 4-methyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 78-79-5 isoprene 

Downstream Products

• 7133-04-2 cis-4-methylcyclohexane carbaldehyde 

Relevant academic research and scientific papers

Hydrogenation of alkenes via cooperative hydrogen atom transfer

Radical hydrogenation via hydrogen atom transfer (HAT) to alkenes is an increasingly important transformation for the formation of thermodynamic alkane isomers. Current single-catalyst methods require stoichiometric oxidant in addition to hydride (H-) source to function. Here we report a new approach to radical hydrogenation: cooperative hydrogen atom transfer (cHAT), where each hydrogen atom donated to the alkene arrives from a different catalyst. Further, these hydrogen atom (H?) equivalents are generated from complementary hydrogen atom precursors, with each alkane requiring one hydride (H-) and one proton (H+) equivalent and no added oxidants. Preliminary mechanistic study supports this reaction manifold and shows the intersection of metal-catalyzed HAT and thiol radical trapping HAT catalytic cycles to be essential for effective catalysis. Together, this unique catalyst system allows us to reduce a variety of unactivated alkene substrates to their respective alkanes in high yields and diastereoselectivities and introduces a new approach to radical hydrogenation.

IL-17 Ligands And Uses Thereof

Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.

Simple, chemoselective hydrogenation with thermodynamic stereocontrol

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

Bis(phosphine)cobalt dialkyl complexes for directed catalytic alkene hydrogenation

Planar, low-spin cobalt(II) dialkyl complexes bearing bidentate phosphine ligands, (P - P)Co-(CH2SiMe3)2, are active for the hydrogenation of geminal and 1,2-disubstituted alkenes. Hydrogenation of more hindered internal and endocyclic trisubstituted alkenes was achieved through hydroxyl group activation, an approach that also enables directed hydrogenations to yield contrasteric isomers of cyclic alkanes.

Axial and equatorial cyclohexylacyl and tetrahydropyranyl-2-acyl radicals. An experimental and theoretical study

(Chemical Equation Presented) Axial and equatorial cyclohexylacyl and tetrahydropyranyl-2-acyl radicals gave distinct EPR spectra thanks to surprisingly large β-hydrogen atom hyperfine splittings that enabled them to be characterized and monitored. DFT computations indicated that the axial species (X = CH2) had a higher barrier to rotation about the (O)Cα-Cα bond. The computed difference ΔH° for the axial and equatorial radicals (R = H, X = CH2) was 0.8 kcal mol -1.

Stereoselective Metal Catalysed Hydroboration of 4-Substituted 1-Methylidenecyclohexanes

Rhodium catalysed hydroboration of 4-substituted 1-methylidenecyclohexanes gives cis-hydroboration products with high stereoselectivity.The effects influencing the stereochemistry are discussed.

Directing Effects in Homogeneous Hydrogenation with PF6

The presence of a ligating group, e.g., OH, CO2Me, C=O, or OMe, on an olefinic substrate is shown to direct the attack of the hydrogenation catalyst PF6/H2/CH2Cl2 from the face of the molecule containing the directing group.Isomerization is a minor side reaction in the cases studied.The origin of this effect is discussed and a model intermediate isolated.