395-21-1

Basic information

• Product Name: 1-fluoro-4-(1-phenylethenyl)benzene
• CAS NO: 395-21-1
• Molecular Formula: C₁₄H₁₁F
• Molecular Weight: 198.2355
• Mol File: 395-21-1.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 277°C at 760 mmHg
• Flash Point: 121.4°C
• Density: 1.065g/cm³
• Vapor Pressure: 0.00783mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 1-fluoro-4-(1-phenylethenyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-(1-phenylethenyl)benzene(395-21-1)
• EPA Substance Registry System: 1-fluoro-4-(1-phenylethenyl)benzene(395-21-1)

Safety Data

• Hazardous Substances Data: 395-21-1(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Molecular weight

208.26 g/mol

Uses

a. Organic synthesis
b. Building block for pharmaceutical and agrochemical compounds

Preparation method

Reaction of 1,4-diphenylbutadiyne with an appropriate fluoroalkylating agent

Significance

Useful intermediate in synthetic organic chemistry

Potential applications

Development of new materials and pharmaceuticals

Upstream product

• 917-64-6 methyl magnesium iodide 
• 345-83-5 4-fluorobenzophenone 
• 352-34-1 4-fluoro-1-iodobenzene 
• 155857-33-3 1--1-phenylethene 
• 14900-39-1 phenylvinylboronic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 98-86-2 acetophenone 
• 1159428-50-8 n-butyl(4-fluorophenyl)tellane 
• 459-32-5 4-fluorocinnamic acid 
• 71-43-2 benzene 
• 350-40-3 2-(4-fluorophenyl)-1-propene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 100-58-3 phenylmagnesium bromide 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 435-38-1 (+/-)-8-(4-fluoro-phenyl)-(4ar)-1,2,3,4,4a,5,6,7-octahydro-1t,4t-etheno-naphthalene-2t,3t,5t,6t-tetracarboxylic acid-2,3;5,6-dianhydride 
• 390-42-1 (E/Z)-3-(4-fluorophenyl)-3-phenylpropenoic acid 
• 47444-86-0 3-(4-fluoro-phenyl)-3-phenyl-acrylic acid-(2-diethylamino-ethyl ester) 
• 345-83-5 4-fluorobenzophenone 
• 43020-10-6 1-(2-methyl-5-phenyl-3-furanyl)ethanone 
• 161115-03-3 1-(5-(4-fluorophenyl)-2-methylfuran-3-yl)ethanone 
• 1342906-43-7 C₂₄H₂₅FO₅ 
• 1192278-61-7 1-fluoro-4-(1-phenylethyl)-benzene 

Relevant articles and documents

Rhodium-Catalyzed meta-Selective C?H Carboxylation Reaction of 1,1-Diarylethylenes via Hydrorhodation-Rhodium Migration

A meta-selective C?H carboxylation reaction of 1,1-diarylethylene derivatives with CO2 by using a rhodium catalyst with NaOiPr as a stoichiometric reductant has been achieved. Together with hydrogenation of the ethylene moiety, a carboxyl group was introduced to the meta-position of the aryl ring with high selectivity over the ortho-positions. Experimental and computational mechanistic studies indicate that this carboxylation reaction proceeds via hydrorhodation on the ethylene moiety, followed by 1,4-rhodium migration and successive 1,2-rhodium migration on the aryl ring. The use of a bulky phosphine ligand seems to be the key to this unusual aryl-to-aryl 1,2-rhodium shift.

Intermolecular [4 + 2] process of N-acyliminium ions with simple olefins for construction of functional substituted-1,3-oxazinan-2-ones

An efficient approach to functionalized 4,6-disubstituted-and 4,6,6-trisubstituted-1,3-oxazinan-2-ones skeleton has been developed through the reaction of semicyclic N,O-acetals 4a and 4b with 1,1-disubstituted ethylenes 5 or 8. As a result of such a [4 +

TMSOTf-mediated synthesis of skipped dienes through the addition of olefins to imines and semicyclicN,O-acetals

A novel approach to skipped dienes has been developed through the TMSOTf-mediated one-pot addition-substitution of olefins2a,2fand2gwith imines1a-1g, and a series of aryl substituted skipped dienes3aa-3gfwere accordingly obtained in 62%-94% yields. Moreov