347-91-1

Basic information

• Product Name: 2-(4-FLUOROPHENYL)ACETOPHENONE
• Synonyms: 2-(4-FLUOROPHENYL)-1-PHENYL ETHANONE;Ethanone, 2-(4-fluorophenyl)-1-phenyl-
• CAS NO: 347-91-1
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.24
• Mol File: 347-91-1.mol
• Article Data: 47

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 325.9°Cat760mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000224mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)ACETOPHENONE(347-91-1)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)ACETOPHENONE(347-91-1)

Safety Data

• Hazardous Substances Data: 347-91-1(Hazardous Substances Data)

Usage

General Description

2-(4-FLUOROPHENYL)ACETOPHENONE, also known as fluoroacetophenone, is a chemical compound with the molecular formula C14H11FO. It is a substituted acetophenone derivative that contains a functional group of a fluorine atom attached to the phenyl ring. 2-(4-FLUOROPHENYL)ACETOPHENONE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It also has potential applications in organic synthesis and as a building block in the production of various fine chemicals. The presence of the fluorine atom makes 2-(4-FLUOROPHENYL)ACETOPHENONE a useful reagent for various transformations in organic chemistry, and it is frequently used as a starting material in the production of new compounds with specific properties. Overall, 2-(4-FLUOROPHENYL)ACETOPHENONE is a versatile chemical with important applications in various industries.

InChI:InChI=1/C14H11FO/c15-13-8-6-11(7-9-13)10-14(16)12-4-2-1-3-5-12/h1-9H,10H2

Upstream product

• 71-43-2 benzene 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 532-27-4 1-chloroacetophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 98-88-4 benzoyl chloride 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 16717-64-9 1-azidostyrene 
• 371-14-2 4-fluorophenylhydrazine 
• 457948-95-7 2-(4-fluorophenyl)-N-methoxy-N-methylacetamide 
• 100-58-3 phenylmagnesium bromide 
• 18511-62-1 4-fluorostyrene oxide 
• 17763-67-6 Phenyl triflate 
• 121039-99-4 C₉H₉FO 

Downstream Products

• 1443223-53-7 2-(4-fluorophenyl)-1-phenyl-2-p-tolylethanone 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Versatile and base-free copper-catalyzed α-arylations of aromatic ketones using diaryliodonium salts

A ligand and base-free copper catalyzed synthetic method for the efficient α-arylation of aromatic ketones is described. In order to avoid strong bases, ketone-derived silyl enol ethers were employed. Their reaction with diaryliodonium salts as aryl source provided the intermolecular C–C coupling displaying good functional group tolerance and requiring low catalyst loading.