3971-28-6

Basic information

• Product Name: 1,3-bis(hydroxymethyl)cyclohexane
• Synonyms: 1,3-bis(hydroxymethyl)cyclohexane;Cyclohexane-1,3-dimethanol;(3-methylolcyclohexyl)methanol;[3-(hydroxymethyl)cyclohexyl]methanol
• CAS NO: 3971-28-6
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21144
• EINECS: 223-594-5
• Mol File: 3971-28-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 222.84°C (rough estimate)
• Flash Point: 131.5°C
• Appearance: /
• Density: 1.0360
• Vapor Pressure: 0.000705mmHg at 25°C
• Refractive Index: 1.4912 (estimate)
• CAS DataBase Reference: 1,3-bis(hydroxymethyl)cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(hydroxymethyl)cyclohexane(3971-28-6)
• EPA Substance Registry System: 1,3-bis(hydroxymethyl)cyclohexane(3971-28-6)

Safety Data

• Hazardous Substances Data: 3971-28-6(Hazardous Substances Data)

Usage

General Description

1,3-bis(hydroxymethyl)cyclohexane is a chemical compound with the molecular formula C8H16O2. It is a cycloalkane derivative with two hydroxymethyl groups attached to the carbon atoms at positions 1 and 3 of the cyclohexane ring. 1,3-bis(hydroxymethyl)cyclohexane is commonly used in organic synthesis and as a building block for the production of various polymers and resins. It is also utilized as a crosslinking agent in the production of plastics, adhesives, and coatings. Additionally, 1,3-bis(hydroxymethyl)cyclohexane has potential applications in the pharmaceutical and agricultural industries, where it may be utilized as an intermediate in the synthesis of various active ingredients. Overall, this chemical plays a significant role in various industrial and research applications due to its unique chemical structure and reactivity.

InChI:InChI=1/C8H16O2/c9-5-7-2-1-3-8(4-7)6-10/h7-10H,1-6H2

Upstream product

• 98837-34-4 ethyl 3-hydroxy-2-methylenebutanoate 
• 140-88-5 ethyl acrylate 
• 10021-92-8 dimethyl cyclohexane-trans-1,3-dicarboxylate 
• 116724-13-1 trans rac-cyclohexyl 1,3-dicarboxylic acid 
• 121-91-5 isophthalic acid 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 1421022-53-8 bis(3-methylcyclohexylmethyl)cyclohexane-1,3-dicarboxylate 
• 1459-93-4 dimethyl Isophthalate 
• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 3971-28-6 (+/-)-trans-1,3-bis-hydroxymethyl-cyclohexane 

Downstream Products

• 3971-28-6 (-)-trans-1,3-bis-hydroxymethyl-cyclohexane 
• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 57702-85-9 1,3-bis-bromomethyl-cyclohexane 
• 111162-61-9 cis-/trans-1,3-Bis(tosyloxymethyl)cyclohexane 
• 111162-61-9 (-)-trans-1,3-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 
• 280-65-9 bicyclo[3.3.1]nonane 
• 4396-95-6 cis-/trans-1,3-Bis(mercaptomethyl)cyclohexane 

Relevant articles and documents

Cis-Dichlorido(3,6,9-trithiabicyclo[9.3.1]pentadecane-κ2 S 3,S 6)palladium(II) acetonitrile 0.8-solvate

In the title complex, [PdCl2(C12H22S 3)]·0.8CH3CN, a potentially tridentate thioether ligand coordinates in a cis-bidentate manner to yield a square-planar environment for the PdII cation [mean deviation of the Pd from the Cl2S2 plane = 0.0406 (7) A]. Each square-planar entity packs in an inverse face-to-face manner, giving pairs with plane-to-plane separations of 3.6225 (12) A off-set by 1.1263 (19) A, with a Pd...Pd separation of 3.8551 (8) A. A partial acetonitrile solvent molecule is present. The occupancy of this molecule was allowed to refine, and converged to 0.794 (10). The synthesis of the previously unreported 3,6,9-trithiabicyclo[9.3.1]pentadecane ligand is also outlined.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

METHOD FOR PREPARING 1,3-CYCLOHEXANEDIMETHANOL

The present invention relates to a method for preparing high-purity 1,3-cyclohexanedimethanol capable of achieving a high conversion rate by allowing most of the reactant to participate in the reaction, and of increasing reaction efficiency and economic efficiency by further simplifying the reaction process, while minimizing by-products within a shorter period of time. Specifically, the method for preparing 1,3-cyclohexanedimethanol includes reducing 1,3-cyclohexanedicarboxylic acid in the presence of a metal catalyst, which is fixed to a silica support and includes a ruthenium (Ru) compound, a tin (Sn) compound and a platinum (Pt) compound in a weight ratio of 1:0.8 to 1.2:1.2 to 2.4.