3971-28-6

Usage

Uses

Used in Organic Synthesis:
1,3-bis(hydroxymethyl)cyclohexane is used as a building block for the synthesis of various organic compounds due to its reactive hydroxymethyl groups, which can be further modified or used to form new chemical entities.
Used in Polymer and Resin Production:
1,3-bis(hydroxymethyl)cyclohexane is used as a monomer in the production of polymers and resins for its ability to form stable covalent bonds with other monomers, contributing to the structural integrity and properties of the resulting materials.
Used in Plastics Industry:
1,3-bis(hydroxymethyl)cyclohexane is used as a crosslinking agent in the production of plastics to enhance their mechanical strength, thermal stability, and resistance to environmental factors.
Used in Adhesives and Coatings:
1,3-bis(hydroxymethyl)cyclohexane is used as a crosslinking agent in adhesives and coatings to improve their adhesion properties, durability, and resistance to wear and tear.
Used in Pharmaceutical Industry:
1,3-bis(hydroxymethyl)cyclohexane has potential applications in the pharmaceutical industry as an intermediate in the synthesis of various active pharmaceutical ingredients, leveraging its reactivity to form new drug molecules.
Used in Agricultural Industry:
1,3-bis(hydroxymethyl)cyclohexane may be utilized in the agricultural industry as an intermediate in the synthesis of active ingredients for pesticides, herbicides, or other agrochemicals, contributing to the development of more effective and environmentally friendly products.

InChI:InChI=1/C8H16O2/c9-5-7-2-1-3-8(4-7)6-10/h7-10H,1-6H2

Upstream product

• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 10021-92-8 dimethyl cyclohexane-trans-1,3-dicarboxylate 
• 116724-13-1 trans rac-cyclohexyl 1,3-dicarboxylic acid 
• 3971-28-6 (+/-)-trans-1,3-bis-hydroxymethyl-cyclohexane 
• 98837-34-4 ethyl 3-hydroxy-2-methylenebutanoate 
• 140-88-5 ethyl acrylate 
• 121-91-5 isophthalic acid 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 1421022-53-8 bis(3-methylcyclohexylmethyl)cyclohexane-1,3-dicarboxylate 
• 1459-93-4 dimethyl Isophthalate 

Downstream Products

• 4396-95-6 cis-/trans-1,3-Bis(mercaptomethyl)cyclohexane 
• 57702-85-9 1,3-bis-bromomethyl-cyclohexane 
• 3971-28-6 (-)-trans-1,3-bis-hydroxymethyl-cyclohexane 
• 111162-61-9 (-)-trans-1,3-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 
• 280-65-9 bicyclo[3.3.1]nonane 
• 111162-61-9 cis-/trans-1,3-Bis(tosyloxymethyl)cyclohexane 
• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 

Relevant academic research and scientific papers

Cis-Dichlorido(3,6,9-trithiabicyclo[9.3.1]pentadecane-κ2 S 3,S 6)palladium(II) acetonitrile 0.8-solvate

In the title complex, [PdCl2(C12H22S 3)]·0.8CH3CN, a potentially tridentate thioether ligand coordinates in a cis-bidentate manner to yield a square-planar environment for the PdII cation [mean deviation of the Pd from the Cl2S2 plane = 0.0406 (7) A]. Each square-planar entity packs in an inverse face-to-face manner, giving pairs with plane-to-plane separations of 3.6225 (12) A off-set by 1.1263 (19) A, with a Pd...Pd separation of 3.8551 (8) A. A partial acetonitrile solvent molecule is present. The occupancy of this molecule was allowed to refine, and converged to 0.794 (10). The synthesis of the previously unreported 3,6,9-trithiabicyclo[9.3.1]pentadecane ligand is also outlined.

Production of Copolyester Monomers from Plant-Based Acrylate and Acetaldehyde

PCTA is an important copolyester that has been widely used in our daily necessities. Currently, its monomers are industrially produced from petroleum-derived xylene. To reduce the reliance on fossil energy, we herein disclose an alternative route to acces

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Catalytic hydrogenation products of aromatic and aliphatic dicarboxylic acids

Hydrogenation of aromatic dicarboxylic acids gave 100 % selectivity to respective cyclohexane dicarboxylic acid with 5 % Pd/C catalyst. 5 % Ru/C catalyst was observed to give over hydrogenation products at 493 K and at lower temperature (453 K) the selectivity for cyclohexane dicarboxylic acids was increased. Hydrogenation of phthalic acid with Ru-Sn/Al2O3 catalyst was observed to give phthalide instead of 1,2-benzene dimethanol or 2-hydroxy methyl benzoic acid. Ru-Sn/Al2O3 catalyst selectively hydrogenated the carboxylic group of cyclohexane dicarboxylic acids to give cyclohexane dimethanol. Use of proper catalysts and reaction conditions resulted in desired products.

METHOD FOR PREPARING 1,3-CYCLOHEXANEDIMETHANOL

The present invention relates to a method for preparing high-purity 1,3-cyclohexanedimethanol capable of achieving a high conversion rate by allowing most of the reactant to participate in the reaction, and of increasing reaction efficiency and economic efficiency by further simplifying the reaction process, while minimizing by-products within a shorter period of time. Specifically, the method for preparing 1,3-cyclohexanedimethanol includes reducing 1,3-cyclohexanedicarboxylic acid in the presence of a metal catalyst, which is fixed to a silica support and includes a ruthenium (Ru) compound, a tin (Sn) compound and a platinum (Pt) compound in a weight ratio of 1:0.8 to 1.2:1.2 to 2.4.

PROCESS FOR THE PREPARATION OF 1,3-CYCLOHEXANEDIMETHANOL FROM ISOPHTHALIC ACID

Disclosed is a process for the preparation of 1,3-cyclohexanedimethanol from isophthalic acid. Isophthalic acid is esterified with (3-methylcyclohexyl)methanol and the isophthalate ester hydrogenated to 1,3-cyclohexanedimethanol in a 2-stage process. The (3-methylcyclohexyl)methanol that is formed during the hydrogenation step is recycled to the esterification reaction. Also disclosed is a method for purifying and recovering the 1,3-cyclohexanedimethanol product.

Preparation of [2.2]-para-, meta-, and orf/ro-cyclophanes containing a 1, 3-cyclohexano group

[2.2]-para-, ineta-, and o/7/w-CycIophanes containing a 1, 3-cyclohexane ring bridged with two carbons were prepared through a coupling reaction to form dithiacyclophane, followed by oxidation to yield the sulfone and then pyrolysis.

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3- P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, low-molecular weight renin inhibitors with improved pharmacokinetic properties.