39735-52-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethyl 2-[(4-chlorobenzoyl)amino]acetate is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, ethyl 2-[(4-chlorobenzoyl)amino]acetate is utilized as a precursor in the production of various agrochemicals. Its chemical properties make it suitable for the synthesis of compounds with pesticidal or herbicidal properties.
Used in Disease Treatment Research:
Ethyl 2-[(4-chlorobenzoyl)amino]acetate has been studied for its potential applications in the treatment of various diseases, including cancer and inflammation. Its chemical structure may offer new avenues for the development of therapeutic agents targeting these conditions.
Used in Organic Chemistry Research:
As a valuable intermediate in organic chemistry, ethyl 2-[(4-chlorobenzoyl)amino]acetate is employed in various research applications. Its reactivity and functional groups make it a versatile building block for the synthesis of complex organic molecules and the exploration of novel chemical reactions.

InChI:InChI=1/C11H12ClNO3/c1-2-16-10(14)7-13-11(15)8-3-5-9(12)6-4-8/h3-6H,2,7H2,1H3,(H,13,15)

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 16794-67-5 p-chlorobenzoyl isothiocyanate 
• 459-73-4 GlyOEt*HCl 
• 116354-02-0 4-Chloro-benzoic acid 4,5-dimethyl-[1,2,3]triazol-1-yl ester 
• 74-11-3 para-chlorobenzoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 122081-18-9 HONC(CH₃)C(CH₃)NNHC(O)C₆H₄Cl-p 

Downstream Products

• 66817-22-9 4-Chloro-N-{[2-(2-hydroxy-3-o-tolyloxy-propylamino)-ethylcarbamoyl]-methyl}-benzamide 
• 66817-28-5 N-({2-[3-(2-Allyloxy-phenoxy)-2-hydroxy-propylamino]-ethylcarbamoyl}-methyl)-4-chloro-benzamide 
• 66817-27-4 N-({2-[3-(2-Allyl-phenoxy)-2-hydroxy-propylamino]-ethylcarbamoyl}-methyl)-4-chloro-benzamide 
• 13450-77-6 4-chlorohippuric acid 
• 38274-54-3 Benurestat 
• 128062-19-1 3-(4-Amino-phenyl)-2-(4-chloro-benzoylamino)-3-oxo-propionic acid ethyl ester 
• 103369-09-1 N-(acetoxymethyl)-4-chloro-benzamide 
• 102674-44-2 N-4-chlorobenzoylglycyl-2-methylalanine 
• 102674-43-1 methyl 4-chlorobenzoylglycyl-2-methylalaninate 
• 102674-45-3 ethyl N-4-chlorobenzoylglycyl-2-methylalanylglycinate 
• 102674-46-4 α-methyl γ-benzyl N-4-chlorobenzoylglycyl-2-methylalanyl-L-glutamate 
• 61786-00-3 ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate 
• 78979-62-1 ethyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate 
• 338770-67-5 2-(4-chlorophenyl)-5-ethoxy-1,3-oxazole 

Relevant academic research and scientific papers

Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives

A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).

Copper-Catalyzed Aerobic Oxidative [2 + 3] Cyclization/Aromatization Cascade Reaction: Atom-Economical Access to Tetrasubstituted 4,5-Biscarbonyl Imidazoles

An atom-economical method for accessing tetrasubstituted 4,5-biscarbonylimidazoles by reaction between glycine derivatives and 5-alkoxyoxazoles is reported. The method, which involves a copper-catalyzed aerobic oxidative [2 + 3] cyclization/aromatization

Substituted pyrimidine derivatives with Akt inhibiting activity, and preparation method and application thereof

The invention relates to novel substituted pyrimidine derivatives with Akt inhibiting activity and a preparation method thereof, a pharmaceutical composition comprising the substituted pyrimidine derivatives and salts thereof, and application of the substituted pyrimidine derivatives and salts thereof in preparing drugs for preventing and/or treating tumors. The structural formula of the compounds is disclosed as Formula (I) or Formula (II). The compounds have the advantages of novel structure, outstanding Akt inhibiting activity, high safety and low preparation cost, and have favorable application prospects in preparing antineoplastic drugs.

Tandem oxidative amidation of benzyl alcohols with amine hydrochloride salts catalysed by iron nitrate

A tandem process for the oxidative amidation of benzyl alcohols with amine hydrochloride salts has been developed using inexpensive Fe(NO3) 3 as the catalyst, air and aqueous t-butyl hydroperoxide as oxidants. A wide range of benzamides have been synthesized under mild conditions. This greener amide formation method provides an economical and practical assess to benzamides from readily available and inexpensive starting materials.

Highly efficient oxidative amidation of aldehydes with amine hydrochloride salts

A mild and efficient copper-catalyzed oxidative amidation of aldehydes was developed using amine HCl salts and tert-butyl hydroperoxide as an oxidant. Copyright

Synthesis of N-(morpholinomethyl) benzamides as moclobemide analogs

Syntheses of new morpholinomethylbenzamides 6 bearing both electron-withdrawing and electron-releasing groups at the aromatic ring are described. The strategy involved synthesis of hippuric acid ethyl esters 3, their hydrolysis to hippuric acids 4, subseq

An efficient one-pot synthesis of hippuric acid ethyl ester derivatives

A rapid, one-pot procedure is described for the preparation of the ethyl esters of a number of ring-substituted N-benzoyl glycine (hippuric acid) derivatives from readily-available starling materials.

Synthesis, structure, and acylating properties of 1-aroyloxy-4,5-dimethyl- 1,2,3-triazoles

Lead tetra-acetate oxidation of α-hydroxyimino aroylhydrazones of biacetyl (1) gives 1-aroyloxy-4,5-dimethyl-1,2,3-triazoles (2), the structures of which were confirmed by X-ray analysis. A mechanism for this reaction is discussed. The products (2) are effective aroylating agents for the amino function under mild conditions.

Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present

The invention relates to compounds with a nitrogen-containing heterocyclic nucleus, of the general formula: STR1 in which: Ar represents a group STR2 or a naphthyl group optionally substituted by a halogen, A represents a heterocyclic nucleus chosen from