39786-36-2

Basic information

• Product Name: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
• Synonyms: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one;3H-Benzofurano[3,2-d]pyrimidin-4-one;4-Hydroxybenzofuro[3,2-d]pyrimidine;Benzofuro[3,2-d]pyrimidin-4(1H)-one;benzofuro[3,2-d]pyriMidin-4-ol;3H-Benzo[4,5]furo[3,2-d]pyriMidin-4-one;Benzofuro[3,2-d]pyrimidin-4(3H)-one;[1]Benzofuro[3,2-d]pyrimidin-4-ol
• CAS NO: 39786-36-2
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.16684
• Mol File: 39786-36-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 277℃
• Boiling Point: 374.5 °C at 760 mmHg
• Flash Point: 180.3 °C
• Appearance: /
• Density: 1.53
• Vapor Pressure: 8.29E-06mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one(39786-36-2)
• EPA Substance Registry System: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one(39786-36-2)

Safety Data

• Hazardous Substances Data: 39786-36-2(Hazardous Substances Data)

Usage

General Description

4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one is a chemical compound with a complex molecular structure. It is a heterocyclic compound containing a benzene ring fused to a pyrimidine ring, and it also contains a lactone functional group. 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one has potential pharmaceutical and biological applications due to its unique structure and properties. It may have therapeutic potential in the fields of medicine and drug development due to its ability to interact with biological systems and potentially modulate biological processes. Further research and analysis of this compound's properties and potential applications are needed to fully understand its capabilities.

InChI:InChI=1/C10H6N2O2/c13-10-9-8(11-5-12-10)6-3-1-2-4-7(6)14-9/h1-5H,(H,11,12,13)

Upstream product

• 39876-88-5 4-Chlorobenzofuro<3,2-d>pyrimidine 
• 54802-10-7 3-aminobenzofuran-2-carboxamide 
• 77287-34-4 formamide 
• 39786-35-1 ethyl 3-aminobenzofuran-2-carboxylate 
• 122-51-0 orthoformic acid triethyl ester 
• 611-20-1 salicylonitrile 
• 1144105-32-7 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidine-2-carboxylic acid 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 75746-17-7 ethyl 3-(ethoxymethylene)amino-2-benzofurancarboxylate 
• 34844-79-6 methyl 2-(2-cyanophenoxy)ethanoate 
• 57805-85-3 methyl 3-amino-2-benzofurancarboxylate 
• 49679-19-8 4-Aminobenzofuro<3,2-d>pyrimidine 
• 75746-19-9 3-amino-3,4-dihydro-4-oxobenzofuro<3,2-d>pyrimidine 

Downstream Products

• 62208-74-6 4-benzylsulfanyl-benzo[4,5]furo[3,2-d]pyrimidine 
• 39876-88-5 4-Chlorobenzofuro<3,2-d>pyrimidine 

Relevant articles and documents

Synthesis of ethyl 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]-pyrimidine-2-carboxylate and its derivatives

The synthesis of ethyl 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidine-2-carboxylates was developed to modify the benzofuro-[3,2-d]pyrimidine heterocyclic system.

Commercial Copper-Catalyzed Aerobic Oxidative Synthesis of Quinazolinones from 2-Aminobenzamide and Methanol

The focus of this study was the development of a new synthetic method for quinazolinones based on the principles of Green Chemistry. Quinazolinones were synthesized from 2-aminobenzamide using methanol as both the C1 source and a green solvent in the presence of base Cs2CO3. Additionally, a commercially available, economical copper complex was used as a catalyst in the reaction. The desired products were achieved in moderate to high yield with up to 99 % isolated yield.

Tyrosine kinase inhibitors. 16. 6,5,6-Tricyclic benzothieno[3,2-d]pyrimidines and pyrimido[5,4-b]- and -[4,5- b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase

Several elaborations of the fundamental anilinopyrimidine pharmacophore have been reported as potent and selective inhibitors of the epidermal growth factor receptor (EGFr) tyrosine kinase. This paper reports on a series of inhibitors whereby some 6,5-bicyclic heteroaromatic systems were fused through their C-2 and C-3 positions to this anilinopyrimidine pharmacophore. Although the resulting tricycles did not produce the enormous potency of some of the (5/6),6,6-bicyclic systems, the best of them had IC50s for the EGFr TK around 1 nM. Investigation of 4-position side chains in the indolopyrimidines confirmed that m-bromoaniline was an optimal substituent for potency. Investigation of substitution within the C-(benzo)ring of benzothienopyrimidines confirmed that introduction of an extra ring can change sharply the effects of substituents when compared to similar bicyclic nuclei, and only two substituents were found which even moderately enhanced inhibitory activity over the parent compound for this series.