398-22-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Chloro-4'-fluorobiphenyl is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to contribute to the development of new and effective compounds.
Used in Medicinal Chemistry Research:
4-Chloro-4'-fluorobiphenyl is utilized as a potential anti-cancer agent, being studied for its effects on cancer cells and its potential to contribute to cancer treatment strategies.
Used in Chemical Research:
As a ligand in organic synthesis, 4-Chloro-4'-fluorobiphenyl is employed in chemical research to explore its properties and applications in the creation of new organic compounds.

Upstream product

• 17151-47-2 tributyl(4-fluorophenyl)stannane 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 324-74-3 4-fluoro-biphenyl 
• 1359844-10-2 2-(4’-fluoro-[1,1’-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 207611-87-8 4,4′-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,1′-biphenyl 
• 28034-99-3 4'-Chloro-4-biphenylol 

Relevant academic research and scientific papers

Manganese-Catalyzed Aerobic Heterocoupling of Aryl Grignard Reagents

An improved protocol has been developed for the MnCl2-catalyzed cross-coupling reaction of two arylmagnesium bromides under dioxygen. The reaction was achieved by using the Grignard reagents in a 2:1 ratio and 20 % of MnCl2. Very good yields of the heterocoupling product were obtained when the limiting Grignard reagent underwent little homocoupling under the reaction conditions. Arylmagnesium bromides that contain p-methoxy, p-(dimethylamino), p-fluoro, and p-chloro substituents were shown to afford high product yields in the cross-coupling reactions with a variety of substituted aryl Grignard reagents. Heterocyclic Grignard reagents, on the other hand, were less effective substrates for this transformation because of the rapid homocoupling of these reagents under the reaction conditions.

Palladium-Catalyzed Stille Cross-Couplings of Sulfonyl Chlorides and Organostannanes

Arene and phenylmethanesulfonyl chlorides can be cross-coupled with aryl, heteroaryl, and alkenylstannanes with desulfitation in the presence of 10 mol % CuBr·Me2S, 1.5 mol % Pd2dba3, and 5 mol % tri-2-furylphosphine in tetrahydrofuran or toluene under reflux. This extension of the Stille cross-coupling reaction realizes a new and economical method for the generation of C?C bonds. The palladium-catalyzed carbonylative Stille cross-coupling reactions of arenesulfonyl chlorides and organostannanes in the presence of CO (60 bar) at 110 °C in toluene generate the corresponding ketones. Arenesulfonyl chlorides are more reactive than aryl chlorides and aryl bromides in their Stille cross-coupling with organostannanes but less reactive than aryl iodides. The new methods disclosed for the generation of C?C bonds open new possibilities for medicinal chemistry and material sciences. Copyright