4-Chloro-4'-fluorobiphenyl

Base Information

Chemical Name:4-Chloro-4'-fluorobiphenyl
CAS No.:398-22-1
Molecular Formula:C12H8ClF
Molecular Weight:206.647
Hs Code.:
DSSTox Substance ID:DTXSID80373941
Nikkaji Number:J1.149.670I
Wikidata:Q82162349
Mol file:398-22-1.mol

Synonyms:4-CHLORO-4'-FLUOROBIPHENYL;398-22-1;1-chloro-4-(4-fluorophenyl)benzene;SCHEMBL7929388;DTXSID80373941

Suppliers and Price of 4-Chloro-4'-fluorobiphenyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 4-Chloro-4'-fluorobiphenyl

Chemical Property:

PSA：0.00000
LogP:4.14610
XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:206.0298561
Heavy Atom Count:14
Complexity:167

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC=C(C=C2)Cl)F

Technology Process of 4-Chloro-4'-fluorobiphenyl

There total 2 articles about 4-Chloro-4'-fluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 352-13-6
4-flourophenylmagnesium bromide

: 2050-68-2
4,4'-dichlorobiphenyl

: 398-22-1
4-chloro-4′-fluoro-1,1′-biphenyl

Guidance literature:: (4-chlorphenyl)magnesium bromide; 4-flourophenylmagnesium bromide; With lithium chloride; manganese(ll) chloride; In tetrahydrofuran; at -10 ℃; Inert atmosphere;

With oxygen; In tetrahydrofuran; at 10 - 20 ℃;
DOI:10.1002/ejoc.201700007

Reference yield:

: 17151-47-2
tributyl(4-fluorophenyl)stannane

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 2050-68-2
4,4'-dichlorobiphenyl

: 398-22-1
4-chloro-4′-fluoro-1,1′-biphenyl

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) bromide dimethylsulfide complex; trifuran-2-yl-phosphane; In tetrahydrofuran; Heating;
DOI:10.1021/ja038328q

Reference yield: 70.0%

: 398-22-1
4-chloro-4′-fluoro-1,1′-biphenyl

: 73183-34-3
bis(pinacol)diborane

: 1359844-10-2
2-(4’-fluoro-[1,1’-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; In toluene; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.8b02228