399-92-8

Basic information

• Product Name: ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE
• Synonyms: ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE;RARECHEM AL BI 1421;(R,S)-2,3,3,3-Tetrafluoro-propionicacidethylester;2,3,3,3-tetrafluoro-propionicacidethylester;Propanoicacid,2,3,3,3-tetrafluoro-,ethylester;R,S-2,3,3,3-Tetrafluoro-propionicacidethylester;Ethyl 2,3,3,3-tetrafluoropropanoate;Ethyl 1H-tetrafluoropropanaote
• CAS NO: 399-92-8
• Molecular Formula: C₅H₆F₄O₂
• Molecular Weight: 174.09
• Mol File: 399-92-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 94-95
• Flash Point: 18.2 °C
• Appearance: /
• Density: 1.353
• Vapor Pressure: 29.5mmHg at 25°C
• Refractive Index: 1.38
• CAS DataBase Reference: ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE(399-92-8)
• EPA Substance Registry System: ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE(399-92-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 399-92-8(Hazardous Substances Data)

Usage

General Description

ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE is a chemical compound with the molecular formula C5H7F4O2. It is a colorless liquid with a fruity odor, and it is primarily used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE is flammable and should be handled with caution. It is also known to be harmful if swallowed, inhaled, or in contact with skin. ETHYL 2,3,3,3-TETRAFLUOROPROPIONATE should be stored in a cool, well-ventilated area away from heat, sparks, and flame. It is important to follow proper safety guidelines when handling and using this chemical.

InChI:InChI=1/C5H6F4O2/c1-2-11-4(10)3(6)5(7,8)9/h3H,2H2,1H3

Upstream product

• 53619-17-3 6-(1,2,2,2-Tetrafluoro-ethyl)-[1,3,2,4,5]dioxadithiazine 2,2,4,4-tetraoxide 
• 64-17-5 ethanol 
• 60-29-7 diethyl ether 
• 40416-27-1 2H-tetrafluoropropionylfluorosulfate 
• 141-78-6 ethyl acetate 
• 392-63-2 N,N'-diethyl-1,2,2,2-tetrafluoropropionamide 
• 7664-93-9 sulfuric acid 
• 1510-84-5 2,3,3,3-tetrafluoro-propionohydroximoyl fluoride; compound with diethyl ether 
• 379-05-5 ethyl 2,3-dibromotrifluoropropionate 
• 380-34-7 1,1,2,3,3,3-hexafluoropropyl ethyl ether 
• 116-15-4 perfluoropropylene 
• 430-71-7 propionyl fluoride 

Downstream Products

• 132998-27-7 2,3,3,3-Tetrafluoro-2-(1-hydroxy-cyclohexyl)-propionic acid ethyl ester 
• 132998-36-8 2-Benzoyl-2,3,3,3-tetrafluoro-propionic acid ethyl ester 
• 16519-02-1 diethyl 2-methyl-2-fluoromalonate 
• 685-88-1 fluoromalonic acid diethyl ester 
• 132998-30-2 2,3,3,3-Tetrafluoro-2-(1-hydroxy-cyclohex-2-enyl)-propionic acid ethyl ester 
• 132998-33-5 2,3,3,3-Tetrafluoro-2-(3-oxo-cyclohexyl)-propionic acid ethyl ester 

Relevant articles and documents

Fluorinated Ketene Dithioacetals. 2. Synthesis of 2-Hydroperfluoro Acid Derivatives from Perfluoroketene Dithioacetals

Perfluoroketene dithioacetals were prepared in high yields from perfluoroaldehyde hydrates via their thioacetalization (TiCl4/CH2Cl2) followed by basic phase transfer catalyzed HF elimination.Acidic hydrolysis (CF3CO2H, H2O) and then transesterification (EtOH, Ti(OiPr)4) yielded S-alkyl 2-hydroperfluoro thioesters and ethyl 2-hydroperfluoro esters, respectively.

Fluorine gas for life science syntheses: Green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

Transformation de l'hexafluoropropene en alcool trifluoroallylique, precurseur des α-fluoroacrylates

The fluoroacryloyl fluoride precursor of α-fluoroacrylic acid esters can arise from an allylic transposition of trifluoroallylic alcohol of which two methods of preparation are presented.In the first, dehydrofluoration of the alcohol CF3CFHCH2OH (4) is used.This alkohol is generated from the ester CF3CFHCOOC2H5 (3).In the second, dehalogenation of the alcohol CF3CFBrCH2OH (10) by zinc is used.The latter is formed by the selective reduction of the ester CF3CFBrCOOC2H5 (9). - Keywords: 2H-Tetrafluoropropanoic acid ester; 2H-Tetrafluoropropanol-1; Trifluoroallylic alcohol; α-Fluoroacryloyl fluoride; NMR spectroscopy