2991-28-8Relevant articles and documents
Proton transfer equilibria between disubstituted benzoic acids and carbinol base of crystal violet in apolar aprotic solvents. Chemometric analysis of disubstituent effects on the strength of benzoic acid in chlorobenzene
Sen Gupta, Susanta K.,Shrivastava, Ruchi
, p. 369 - 373 (2008/09/19)
Proton transfer equilibria in chlorobenzene between a set of di-substituted (2,3-,2,5-,2,6-, 3,5-dichloro and difluoro) benzoic acids including the corresponding mono-substituted acids and the carbinol base of crystal violet have been studied spectrophotometrically. To investigate the effect of disubstitution at ortho- and/or meta- positions on the strength of benzoic acid, the results have been analysed chemometrically on the basis of Fujita Nishioka's multiparameter approach and the assumption of additivity for substituent effects. The model employed explains 94% of the variance for the disubstituent effects on log K. It is observed that the substituent effect is contributed by ordinary electronic and proximity electronic effects in an almost equal ratio (52:48).
Process for the preparation of fluorinated benzoic acids
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, (2008/06/13)
In the process for the preparation of fluorinated benzoic acids of the formula I STR1 in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover denotes bromine, a fluorinated chloroacetophenone of the formula II STR2 in which Z denotes chlorine or hydrogen, is reacted with a hypohalite.
Synthesis of 1-fluoro-, 4-fluoro-, and 1,4-difluoro-4-demethoxydaunomycinone. Interesting D-ring analogues of adriamycin
Morrow,Swenton,Filppi,Wolgemuth
, p. 713 - 719 (2007/10/02)
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