40154-38-9

Upstream product

• 100-52-7 benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 

Downstream Products

• 18440-50-1 N-benzyl-N'-benzylidene-4-methylbenzenesulfonohydrazide 
• 908094-04-2 phenyldiazomethane 
• 32508-90-0 benzyl n-heptylketone 
• 329359-42-4 1,3-diphenyl-decan-2-one 
• 2001-28-7 2-phenyl-1-p-tolyl-ethanone 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 3769-84-4 p-nitrodeoxybenzoin 
• 451-40-1 phenyl benzyl ketone 
• 1232-40-2 1,1,3-triphenyl-2-propanone 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 16216-13-0 2-phenyl-1-o-tolylethanone 
• 61259-29-8 1-cyclohexyl-2-phenylethanone 
• 53226-67-8 trans-2-phenyl-3-[(E)-2-phenyl-1-ethenyl] oxirane 
• 205931-96-0 trans-(2R,3R)-2-phenyl-3-[(E)-2-phenyleth-1-enyl]oxirane 

Relevant academic research and scientific papers

[Co(MeTAA)] Metalloradical Catalytic Route to Ketenes via Carbonylation of Carbene Radicals

An efficient synthetic strategy towards beta-lactams, amides, and esters involving “in situ” generation of ketenes and subsequent trapping with nucleophiles is presented. Carbonylation of carbene radical intermediates using the cheap and highly active cobalt(II) tetramethyltetraaza[14]annulene catalyst [Co(MeTAA)] provides a convenient one-pot synthetic protocol towards substituted ketenes. N-tosylhydrazones are used as carbene precursors, thereby bridging the gap between aldehydes and ketenes. Activation of these carbene precursors by the metalloradical cobalt(II) catalyst affords CoIII-carbene radicals, which subsequently react with carbon monoxide to form ketenes. In the presence of a nucleophile (imine, alcohol, or amine) in the reaction medium the ketene is immediately trapped, resulting in the desired products in a one-pot synthetic protocol. The β-lactams formed upon reaction with imines are produced in a highly trans-selective manner.

Synthesis of new pyrazolines and their biological evaluation as antimicrobial agents

2-Diazopropane and diazo compounds derived from aromatic aldehydes were reacted with aromatic esters of 3- hydroxyprop-1-yne to give the aromatic esters of 5-hydroxymethyl-3-substituted pyrazoles. Anti-microbial screening using the Gram positive (Staphylo

Synthesis of 3,5-disubstituted pyrazole derivatives with a carbamate function

One-pot reaction of 1,3-dipolar cycloaddition of aryldiazamethanes generated in situ from the sodium salts of tosylhydrazones of benzaldehyde, p-nitro-, p-methoxy-, and 3,4-dimethoxybenzaldehyde to propargyl-N-phenyl carbamate under heating led to the for

Catalytic asymmetric synthesis of epoxides from aldehydes using sulfur ylides with in situ generation of diazocompounds

A practical, general, and convergent to epoxides with control of the relative and absolute stereochemistry has been achieved by generating the reactive intermediate (the diazo compound) in situ from tosylhydrazone salts (see scheme, PTC = phase-transfer catalyst, Ts = toluene-4-sulfonyl). High yields (58-82%), high d.r. (88:12-98:2), and high ee values (87-94%) have been obtained using a new class of stable chiral sulfides at low catalyst loading (5 mol%) and [Rh2(OAc)4] (0.5 mol%).

Laser flash photolysis study of phenylcarbene, o-tolylcarbene and mesitylcarbene

Laser flash photolysis (LFP, XeCl, 308 nm, 20 ns) of phenyldiazomethane (PDM), o-tolydiazomethane (TDM) and mesitydiazomethane (MDM) produces phenylcarbene (PC), o-tolycarbene (TC) and mesitylcarbene (MSC), respectively. Transient spectra of PC and TC cou