40164-60-1

Upstream product

• 85808-33-9 2-amino-4-phenylbutyric acid methylester hydrochloride 
• 98-80-6 phenylboronic acid 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 1939-99-7 benzenesulfonyl chloride 
• 492-38-6 2-phenylacrylic acid 
• 103-82-2 phenylacetic acid 
• 451-40-1 phenyl benzyl ketone 
• 23215-60-3 2-benzyl-2-phenylbenzothiazoline 
• 401636-52-0 di-tert-butyl 4-benzyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 122-78-1 phenylacetaldehyde 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 3412-44-0 1,3-diphenylpropene 

Relevant academic research and scientific papers

Photocatalytic Hydromethylation and Hydroalkylation of Olefins Enabled by Titanium Dioxide Mediated Decarboxylation

A versatile method for the hydromethylation and hydroalkylation of alkenes at room temperature is achieved by using the photooxidative redox capacity of the valence band of anatase titanium dioxide (TiO2). Mechanistic studies support a radical-based mechanism involving the photoexcitation of TiO2 with 390 nm light in the presence of acetic acid and other carboxylic acids to generate methyl and alkyl radicals, respectively, without the need for stoichiometric base. This protocol is accepting of a broad scope of alkene and carboxylic acids, including challenging ones that produce highly reactive primary alkyl radicals and those containing functional groups that are susceptible to nucleophilic substitution such as alkyl halides. This methodology highlights the utility of using heterogeneous semiconductor photocatalysts such as TiO2 for promoting challenging organic syntheses that rely on highly reactive intermediates.

Benzothiazolines as radical transfer reagents: Hydroalkylation and hydroacylation of alkenes by radical generation under photoirradiation conditions

Novel radical transfer reagents under photoirradiation conditions were developed by the use of benzothiazoline derivatives. These reagents enabled both hydroalkylation and hydroacylation of alkenes under neutral conditions at ambient temperature without a

Substituted Hantzsch Esters as Versatile Radical Reservoirs in Photoredox Reactions

Substituted Hantzsch esters can act as radical reservoirs in photoredox reactions, steadily releasing a carbon radical and a hydrogen atom radical in the absence of an additional electron acceptor. We propose that radical release by substituted Hantzsch esters occurs via a mechanism involving an internal redox cycle. Cinnamidecinnamides, styrenes, α,β-unsaturated acids, and diarylethenes could be alkylated smoothly with these reagents. (Figure presented.).

Photocatalytic Radical Alkylation of Electrophilic Olefins by Benzylic and Alkylic Zinc-Sulfinates

Alkyl radicals are obtained by photocatalytic oxidation of readily prepared or commercially available zinc sulfinates. The convenient benzylation and alkylation of a variety of electron-poor olefins triggered by the iridium(III) complex 6 Ir[dF(CF3)ppy]2(dtbbpy)PF6 as photocatalyst is described. Moreover, it is shown that zinc sulfinates can be used for facile nonradical sulfonylation reactions with highly electrophilic Michael acceptors.

Parameters Influencing Reactivity and Regioselectivity in the Methoxycarbonylation of Arylalkenes

Previous research showed that the steric bulk, electronic character, and bite angle of the ligand have an influence on both the catalyst activity and regioselectivity of hydroformylation and hydroesterification reactions. However, little is known in this regard about the influence of the steric and electronic environment around the double bond of the substrate. A variety of arylalkenes were therefore subjected to methoxycarbonylation to investigate the steric and electronic effects of substituents on the aromatic ring of the substrate on the regioselectivity and reactivity in the methoxycarbonylation reaction of these substrates with a Pd(II)/Al(OTf)3/Ph3P catalyst system.

Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.

Photochemical Addition of Tertiary Amines to Electrophilic Cyclopropranes via Single Electron Transfer

Irradiation of arylcyclopropanes bearing at least one electron-withdrawing group with a tertiary amine in acetonitrile resulted in the formation of the regioselective addition product of the amine along with the reduction product.