40230-24-8Relevant articles and documents
Synthesis and biological evaluation of novel imidazopyrimidin-3-amines as anticancer agents
Mahdavi, Mohammad,Dianat, Shima,Khavari, Behnaz,Moghimi, Setareh,Abdollahi, Mohammad,Safavi, Maliheh,Mouradzadegun, Arash,Kabudanian Ardestani, Sussan,Sabourian, Reyhaneh,Emami, Saeed,Akbarzadeh, Tahmineh,Shafiee, Abbas,Foroumadi, Alireza
, p. 797 - 805 (2017)
Groebke–Blackburn–Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, an
Synthesis and characterization of antitubercular triazine-chalcone hybrid molecules
Rawat, Aman,Kaur, Atinder,Surjit,Kaur, Harpreet
, p. 2084 - 2090 (2017)
A new series of 1,3,5-triazine-chalcone hybrid molecules have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC)
Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors
Kayamba, Francis,Malimabe, Teboho,Ademola, Idowu Kehinde,Pooe, Ofentse Jacob,Kushwaha, Narva Deshwar,Mahlalela, Mavela,van Zyl, Robyn L.,Gordon, Michelle,Mudau, Pertunia T.,Zininga, Tawanda,Shonhai, Addmore,Nyamori, Vincent O.,Karpoormath, Rajshekhar
, (2021/03/22)
Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative antimalarial therapies are urgently needed. In line with this
Copper-catalyzed three-component formal [3 + 1 + 2] annulations for the synthesis of 2-aminopyrimidines fromO-acyl ketoximes
Chen, Hongbiao,Deng, Guo-Jun,Huang, Huawen,Xu, Zhenhua
supporting information, p. 8706 - 8710 (2021/10/22)
A copper-based catalytic system has been developed to enable formal [3 + 1 + 2] annulations of ketoxime acetates, aldehydes, and cyanamides. This protocol offers a new strategy for the synthesis of highly substituted 2-aminopyrimidine compounds, and more importantly, pyrimidines have now been included in the N-heterocycle family constructed usingO-acyl ketoximes as N-C-C synthons.