4031-81-6

Usage

InChI:InChI=1/C8H7ClN2O3/c1-5(12)10-8-4-6(11(13)14)2-3-7(8)9/h2-4H,1H3,(H,10,12)

Upstream product

• 64-19-7 acetic acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 75-36-5 acetyl chloride 
• 7664-93-9 sulfuric acid 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 7697-37-2 nitric acid 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 108-24-7 acetic anhydride 
• 95-51-2 o-chloroaniline 

Downstream Products

• 200403-70-9 acetic acid-(2-methylsulfanyl-5-nitro-anilide) 
• 2810-45-9 chloro-acetic acid-(N-methyl-3-nitro-anilide) 
• 5367-36-2 4-(N,N-dimethylamino)-3-acetamidonitrobenzene 
• 959855-42-6 2-methyl-1-(2-methylphenyl)-5-nitro-1H-benzimidazole 
• 1219134-64-1 N-[4-chloro-3-(1-methylpiperidin-4-ylamino)phenyl]benzenesulfonamide 
• 926208-07-3 N-(4-chloro-3-amino-phenyl)benzenesulfonamide 
• 1219135-11-1 N-(4-chloro-3-acetamido-phenyl)benzenesulfonamide 
• 78228-01-0 2-(methylthio)-5-nitroaniline 
• 453562-68-0 1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone 
• 2941-66-4 2-methyl-5-nitrobenzothiazole 
• 100872-81-9 acetic acid-(5-nitro-2-phenoxy-anilide) 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

New method for the preparation of N-chloroamines by oxidative N-halogenation of amines using oxone-KCl

A mild and efficient method for preparation of N-chloroamines by oxidative N-halogenation of primary/secondary amines using oxone-KCl is described.

ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS

The present invention relates to novel aryl sulfonamide amine compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein

HETEROCYCLIC COMPOUNDS AND THEIR USES

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

A palladium-catalyzed regiospecific synthesis of N-aryl benzimidazoles

(Chemical Equation Presented) Highly tolerated: A catalytic method employing [Pd2(dba)3] and XPhos or RuPhos permits the efficient synthesis of N-aryl benzimidazoles in regioisomerically pure form starting from ortho-halo-anilides (see scheme), and tolerates a wide range of functional groups, dba = trans,trans-dibenzylideneacetone.

Synthesis of substituted nitrooxindoles via intramolecular oxidative nucleophilic substitution of hydrogen in m-nitroacylanilides

A simple method of the synthesis of substituted nitrooxindoles via intramolecular oxidative nucleophilic substitution of hydrogen is described.

Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use

Method for dyeing keratinous fibres, in particular human keratinous fibres, such as hair, characterized in that a composition (A) containing, in a medium appropriate for dyeing, at least one aminoindole corresponding to the formula: STR1 in which: R1 and R3, independently of one another, represent a hydrogen atom or a C1 -C4 alkyl group; R2 denotes hydrogen or a C1 -C4 alkyl group or COOR', R' being a hydrogen atom or a C1 -C4 alkyl group; R4 represents a hydrogen atom or a C1 -C4 alkyl, C1 -C4 hydroxyalkyl or C2 -C4 polyhydroxyalkyl group; Z1 represents a hydrogen or halogen atom or a C1 -C4 alkyl group or OR; R being a hydrogen atom or a C1 -C4 alkyl group; and Z2 represents a hydrogen atom or a C1 -C4 alkyl group; and its salts is applied to said fibres, the colour being developed with the aid of an oxidizing system.