40310-35-8

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 106-39-8 bromochlorobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1003-09-4 2-bromothiophene 
• 104-88-1 4-chlorobenzaldehyde 
• 122-01-0 4-chloro-benzoyl chloride 
• 4153-45-1 2-(4-chlorobenzoyl)thiophene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 1026413-29-5 2-[(4-Chloro-phenyl)-thiophen-2-yl-methoxy]-ethanol 
• 1026301-06-3 Methanesulfonic acid 2-[(4-chloro-phenyl)-thiophen-2-yl-methoxy]-ethyl ester 
• 128173-85-3 3-Piperidinecarboxylic acid, 1-[2-[(4-chlorophenyl)-2-thienylmethoxy]ethyl]- 
• 1009808-33-6 2-[(4-chlorophenyl)-thiophen-2-yl-methyl]phenol 
• 1009807-97-9 C₁₇H₁₃ClOS 
• 135887-30-8 C₂₂H₁₆Cl₂OS₂ 

Relevant academic research and scientific papers

Thiophene containing trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis

Triarylmethanes (TRAMs) and thiophene containing trisubstituted methanes (TRSMs) have been reported by us, having potential against Mycobacterium tuberculosis and Mycobacterium fortuitum strains, respectively. Further, extension through synthesis and biol

Chirality control in the enantioselective arylation of aromatic aldehydes catalyzed by cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid derived 1,3-aminoalcohols

A series of chiral 1,3-aminoalcohols derived from cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid were synthesized and applied to the enantioselective arylation of aromatic aldehydes. The reactions exhibited good yields (up to 90%) and moderate to high

Design, synthesis and antitubercular activity of compounds containing Aryl and heteroaryl groups with alkylaminoethyl chains

Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37RV and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubcrcular activity. Among heteroaryl containing triarylmcthanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.

Thiophene containing triarylmethanes as antitubercular agents

A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-12.5 μg/mL in vitro.

Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation

1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles (DAMNIs) is a novel family of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentration. Replacement of one phenyl ring of 1-[2-(diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole (4) with heterocyclic rings, such as 2-thienyl or 3-pyridinyl, led to novel DAMNIs with increased activity. In HIV-1 WT cell-based assay the racemic 1-{2-[α-(thiophen-2-yl) phenylmethoxy]ethyl}-2-methyl-5-nitroimidazole (7) (EC50 = 0.03 μM) proved 5 times more active than compound 4. Docking experiments showed that the introduction of a chiral center would not affect the binding of both (R)-7 and (S)-7. The internal scoring function of the Autodock program calculated the same inhibition constant (Ki = 7.9 nM) for the two enantiomers. Compounds 7 (ID50 = 8.25 μM) were found more active than efavirenz (ID50 = 25 μM) against the viral RT carrying the K103N mutation, suggesting for these compounds a potential use in efavirenz based anti-AIDS regimens.

Photochemical reactions of Thienyl-, Bithienyl-, Terthienyl- and Thienylaroyl-methanols

Photochemical reactions of some thienyl-, bithienyl-, terthienyl- and thienylaroyl-methanols were studied in the neat state as well as in solvents like methanol and benzene.The terthienylmethanols were found to be susceptible to photo-sensitized oxidation which was inhibited by singlet oxygen quenchers.The photoproducts were isolated, characterised by spectroscopic methods and in some cases by synthesis.