4153-45-1

Basic information

• Product Name: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE
• Synonyms: ART-CHEM-BB B020314;AKOS B020314;AKOS 94087;(4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE
• CAS NO: 4153-45-1
• Molecular Formula: C₁₁H₇ClOS
• Molecular Weight: 222.69
• Mol File: 4153-45-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(4153-45-1)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE(4153-45-1)

Safety Data

• Hazardous Substances Data: 4153-45-1(Hazardous Substances Data)

Usage

General Description

(4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE is a chemical compound with the molecular formula C12H8Cl2OS. It is a yellow solid with a molecular weight of 277.16. (4-CHLORO-PHENYL)-THIOPHEN-2-YL-METHANONE is used in pharmaceutical and chemical research as a building block for various organic synthesis processes. It is a derivative of thiophene, containing a chlorine-substituted phenyl group. The compound's structure and properties make it suitable for use in the development of new drugs and materials with potential applications in various industries.

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 
• 3437-95-4 2-Iodothiophene 
• 201230-82-2 carbon monoxide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 527-72-0 2-thiophenylcarboxylic acid 
• 145091-61-8 thiophen-2-ylmanganese(II) chloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 98-03-3 thiophene-2-carbaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 74-11-3 para-chlorobenzoic acid 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 249513-43-7 trifluoromethanesulfonic acid 5-(4-chlorobenzoyl)thiophen-2-yl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 949934-44-5 (4-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl](thien-2-yl)methanol 
• 135887-30-8 C₂₂H₁₆Cl₂OS₂ 
• 40310-35-8 (4-chlorophenyl)-(thiophen-2-yl)methanol 
• 25706-30-3 2-(4-Aminobenzoyl)thiophene 

Relevant articles and documents

One-Pot Synthesis of Arylketones from Aromatic Acids via Palladium-Catalyzed Suzuki Coupling

A palladium-catalyzed one-pot procedure for the synthesis of aryl ketones has been developed. Triazine esters when coupled with aryl boronic acids provided aryl ketones in moderate to excellent yields (up to 95%) in the presence of 1 mol % Pd(PPh3)2Cl2 for 30 min. (Chemical Equation Presented).

Palladacycle-Catalyzed Carbonylative Suzuki-Miyaura Coupling with High Turnover Number and Turnover Frequency

This work reports the carbonylative Suzuki-Miyaura coupling of aryl iodides catalyzed by palladacycles. More importantly, the palladacycles have been used to generate high turnover numbers (TON's) and turnover frequencies (TOF's). A range of aryl iodides can be coupled with arylboronic acids, generating TON's in the range of 106 to 107 and TOF's in the range of 105 to 106 h-1. Comparison of the palladacycles with a conventional palladium source shows their superiority in generating high TON's and TOF's.

TFAA/H3PO4-Mediated C-2 acylation of thiophene: A direct synthesis of known and novel thiophene derivatives of pharmacological interest

A number of aliphatic and aromatic carboxylic acids were reacted with thiophene in the presence of trifluoroacetic anhydride and H3PO 4 to give a variety of acylated thiophenes in good to excellent yields. The methodology was used to prepare known nonsteroidal anti-inflammatory drug-based novel compounds of potential pharmacological significances. Molecular modeling studies were carried out by using nonsteroidal anti-inflammatory drug-based thiophene derivatives to assess their cyclooxygenase inhibiting potential in silico. On the basis of docking studies followed by subsequent in vitro assay, indomethacin-based thiophene derivative was identified as a novel cyclooxygenase-2 inhibitor with balanced selectivity.