4038-15-7

Basic information

• Product Name: 2,4,4'-TRIMETHOXYBENZOPHENONE
• Synonyms: 2,4,4'-TRIMETHOXYBENZOPHENONE;(2,4-dimethoxyphenyl)-(4-methoxyphenyl)methanone
• CAS NO: 4038-15-7
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.3
• Mol File: 4038-15-7.mol

Chemical Properties

• Melting Point: 71-73°C
• Boiling Point: 444°Cat760mmHg
• Flash Point: 197.9°C
• Appearance: /
• Density: 1.136g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1991889
• CAS DataBase Reference: 2,4,4'-TRIMETHOXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,4'-TRIMETHOXYBENZOPHENONE(4038-15-7)
• EPA Substance Registry System: 2,4,4'-TRIMETHOXYBENZOPHENONE(4038-15-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 4038-15-7(Hazardous Substances Data)

Usage

Preparation

Obtained by heating of its oxime with pyridinium chloride containing 10% of –water.

Upstream product

• 39828-35-8 2,4-dimethoxybenzoyl chloride 
• 100-66-3 methoxybenzene 
• 100-09-4 4-methoxybenzoic acid 
• 151-10-0 1,3-Dimethoxybenzene 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 1470-79-7 2,4,4'-trihydroxy-benzophenone 
• 77-78-1 dimethyl sulfate 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 109384-40-9 (2,4-dimethoxyphenyl)zinc chloride 
• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 

Downstream Products

• 102751-95-1 (2,4-Dimethoxy-phenyl)-(4-methoxy-phenyl)-phenyl-methanol 
• 1470-79-7 2,4,4'-trihydroxy-benzophenone 
• 53039-53-5 2,4-dimethoxy-1-(4-methoxybenzyl)benzene 
• 23997-81-1 (2,4-dimethoxyphenyl)(4-methoxyphenyl)methanone oxime 
• 6131-38-0 2-hydroxy-4,4'-dimethoxybenzophenone 
• 77901-45-2 5-(2,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-5H-[1,2,3,4]dioxadiazole 
• 159595-96-7 1-(2,4-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-yn-1-ol 

Relevant articles and documents

Synthesis and Photochromism of Novel Pyridyl-Substituted Naphthopyrans

Multitarget synthetic strategies to access novel photochromic 3H-naphtho[2,1-b]pyrans decorated with pyridyl units are described. The new pyridyl-substituted 3H-naphtho[2,1-b]pyrans display good photochromic properties with reversible generation of photomerocyanines, which exhibit mainly orange/red hues. Photochromic parameters including photocolorability and persistence of color vary tremendously on structural modification of the naphthopyran core.

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase (AR), α-glucosidase, and α-am

The compound of the chemical species generated

A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.

REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES

A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.

Efficient Synthesis of Diaryl Ketones by Nickel-Catalyzed Negishi Cross-Coupling of Amides by Carbon–Nitrogen Bond Cleavage at Room Temperature Accelerated by a Solvent Effect

The first Negishi cross-coupling of amides for the synthesis of versatile diaryl ketones by selective C?N bond activation under exceedingly mild conditions is reported. The cross-coupling was accomplished with bench-stable, inexpensive precatalyst [Ni(PPh3)2Cl2] that shows high functional-group tolerance and enables the synthesis of highly functionalized diaryl ketone motifs. The coupling occurred with excellent chemoselectivity favoring the ketone (cf. biaryl) products. Notably, this process represents the mildest conditions for amide N?C bond activation accomplished to date (room temperature, 10 min). Considering the versatile role of polyfunctional biaryl ketone linchpins in modern organic synthesis, availability, and excellent functional-group tolerance of organozinc reagents, this strategy provides a new platform for amide N?C bond/organozinc cross-coupling under mild conditions.

Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives

In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions of benzoic acids with substituted b

An air-tolerant approach to the carbonylative suzuki-miyaura coupling: Applications in isotope labeling

Carbonylative Suzuki-Miyaura coupling conditions have been developed that proceed without the exclusion of oxygen and in the presence of nondegassed and nondried solvents. By adapting the method to a two-chamber setup, the direct handling of carbon monoxide, produced from stable CO precursors, is avoided. The protocol afforded the desired benzophenones with excellent functional group tolerance and in good yields. Substituting the CO precursor, in the CO-producing chamber, with its carbon-13 labeled version generated the corresponding carbon-13 labeled benzophenones. Finally, the developed system was applied in the synthesis and isotope labeling of two pharmaceuticals, nordazepam and Tricor.

3,3-bis(aryl)-5-((N-(un)substituted)amido)naphthopyrans, their preparation, compositions and (co)polymer matrices containing them

The object of the present invention is novel naphthopyran compounds as well as the compositions and (co)polymer matrices containing them. Said compounds have interesting photochromic properties. Another object of the present invention is a method of preparing said novel compounds.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.