BIOLOGICALLY ACTIVE ACETOGENINS FROM STEM BARK OF ASIMINA TRILOBA

Article abstract of DOI:10.1016/0031-9422(93)85024-L

In continuing our research with cytotoxic and pesticidal components from the stem bark of the North American paw paw, Asimina triloba, the novel cytotoxic monotetrahydrofuran Annonaceous acetogenis, cis- and trans-annonacin-A-one, cis- and trans-gigantetrocinone and cis-isoannonacin, in addition to the known compounds, trans-isoannonacin and squamolone, have been identified.Brine shrimp lethalty testing was used to direct the fractionation.The structures were elucidated by spectral analysis and/or chemical synthesis.These acetogenins have potent cytotoxicities against the human tumor cell lines of A-549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-29 (colon adenocarcinoma). Key Word Index: Asimina triloba; Annonaceae; stem bark; acetogenins; cis- and trans-annonacin-A-one; cis- and trans-gigantetrocinone; cis- and trans-isoannonacin; squamolone.