40527-16-0Relevant academic research and scientific papers
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription
Struntz, Nicholas B.,Chen, Andrew,Deutzmann, Anja,Wilson, Robert M.,Stefan, Eric,Evans, Helen L.,Ramirez, Maricela A.,Liang, Tong,Caballero, Francisco,Wildschut, Mattheus H.E.,Neel, Dylan V.,Freeman, David B.,Pop, Marius S.,McConkey, Marie,Muller, Sandrine,Curtin, Brice H.,Tseng, Hanna,Frombach, Kristen R.,Butty, Vincent L.,Levine, Stuart S.,Feau, Clementine,Elmiligy, Sarah,Hong, Jiyoung A.,Lewis, Timothy A.,Vetere, Amedeo,Clemons, Paul A.,Malstrom, Scott E.,Ebert, Benjamin L.,Lin, Charles Y.,Felsher, Dean W.,Koehler, Angela N.
, p. 711 - 14,723 (2019/05/21)
The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins. Among this dynamic network of interactions, the Myc/Max heterodimer has
MAX BINDERS AS MYC MODULATORS AND USES THEREOF
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, (2017/09/02)
The present disclosure provides compounds of Formula (I′), Formula (I), Formula (II), Formula (II-A), Formula (III), and Formula (IV). The compounds described herein are MAX binders and/or modulators of Myc, Mad, or Mxi1 (e.g., inhibitors of Myc, Mad, or
Titanium-catalyzed stereoselective synthesis of spirooxindole oxazolines
Badillo, Joseph J.,Arevalo, Gary E.,Fettinger, James C.,Franz, Annaliese K.
supporting information; experimental part, p. 418 - 421 (2011/04/15)
A regio-and stereoselective cyclization between isatins and 5-methoxyoxazoles has been developed using catalytic titanium (IV) chloride (10 or 20 mol %) to afford spiro[3,3'-oxindoleoxazolines] in excellent yield (up to 99%) and diastereoselectivity (dr >
A novel preparation of 2-aryl-5-methoxyoxazoles
Xia
, p. 382 - 383 (2007/10/03)
2-Aryl-5-methoxyoxazoles can be synthesized by oxidation of Schiff's bases with (diacetoxyiodo) benzene in good yields under mild conditions.
Vilsmeier-Haack reagent: A facile synthesis of 4-heteromethylene-2-aryl-2-oxazolin-5-ones from N-acyl-α-amino acid esters
Singh, Kumar K,Singh, Radhey M
, p. 232 - 235 (2007/10/02)
4-(N,N-dimethylaminomethylene)-2-aryl-2-oxazolin-5-ones (5) have been synthesised from N-acyl-α-amino acid esters (3) by treating with Vilsmeier-Haack reagent, in good yield.The variable temperature-NMR study and a plausible mechanism have also been discu
Synthesis and Thermolysis of 5-Azido-4-formyloxazoles
L'abbe, Gerrit,Ilisiu, Anna-Maria,Dehaen, Wim,Toppet, Suzanne
, p. 2259 - 2262 (2007/10/02)
5-Azidooxazole-4-carbaldehydes 5a-c have been prepared from the corresponding chloro aldehydes and found to be unstable in solution at room temperature.Whereas the phenyl derivative 5a decomposed with loss of nitrogen and formation of the imine 6 which wa
