40556-79-4

Upstream product

• 6051-13-4 2-cyclohexylpropanoic acid 
• 110-82-7 cyclohexane 
• 292638-85-8 acrylic acid methyl ester 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 62184-70-7 methyl 2-(1-cyclohexenyl)propanoate 
• 31042-01-0 methyl (1-hydroxy-α-methylcyclohexane)acetate 
• 14352-61-5 methyl cyclohexylacetate 
• 74-88-4 methyl iodide 
• 103-26-4 methyl cinnamate 
• 108-94-1 cyclohexanone 
• 110-83-8 cyclohexene 

Downstream Products

• 6051-13-4 2-cyclohexylpropanoic acid 
• 116505-07-8 2-cyclohexylpropanoyl chloride 
• 65426-80-4 2-Cyclohexyl-propancarbonsaeure-p-nitrophenylester 
• 86769-66-6 methyl 2-cyclohexyl-2-methylpropanoate 
• 20474-47-9 cyclohexyl-2 pentanone-3 
• 1534433-51-6 2-cyclohexyl-3-(4-methoxyphenyl)-N-(quinolin-8-yl)propanamide 
• 1534433-39-0 2-cyclohexyl-N-(quinolin-8-yl)propanamide 

Relevant academic research and scientific papers

Synthesis of (+)-discodermolide by catalytic stereoselective borylation reactions

The marine natural product (+)-discodermolide was first isolated in 1990 and, to this day, remains a compelling synthesis target. Not only does the compound possess fascinating biological activity, but it also presents an opportunity to test current methods for chemical synthesis and provides an inspiration for new reaction development. A new synthesis of discodermolide employs a previously undisclosed stereoselective catalytic diene hydroboration and also establishes a strategy for the alkylation of chiral enolates. Furthermore, this synthesis of discodermolide provides the first examples of the asymmetric 1,4-diboration of dienes and borylative diene-aldehyde couplings in complex-molecule synthesis. Borylation-based synthesis: The development of a strategy for stereocontrol in catalytic diene hydroboration enables the synthesis of a critical building block for the assembly of (+)-discodermolide. Combined with asymmetric catalytic diboration, hydroformylation, and borylative aldehyde-diene coupling reactions, (+)-discodermolide could then be prepared from simple hydrocarbon-based building blocks.

Nickel-catalyzed direct arylation of C(sp3)-H bonds in aliphatic amides via bidentate-chelation assistance

The Ni-catalyzed, direct arylation of C(sp3)-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as a bidentate directing group with aryl halides is described. Deuterium-labeling experiments indicate that the C-H bond cleavage step is fast and reversible. Various nickel complexes including both Ni(II) and Ni(0) show a high catalytic activity. The results of a series of mechanistic experiments indicate that the catalytic reaction does not proceed through a Ni(0)/Ni(II) catalytic cycle, but probably through a Ni(II)/Ni(IV) catalytic cycle.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.

Process for the preparation of methyl cyclohexyl-propionate

Methyl cyclohexyl-propionate is prepared by the hydrogenation of methyl cinnamate in the presence of a ruthenium and/or palladium catalyst.

A catalytic stereo- and chemo-selective method for the reduction of substituted aromatics

Various substituted aromatics have been reduced using colloidal ruthenium under H2 pressure with good stereoselectivity (cis/trans up to 60). Interesting chemoselectivities are also observed.

Thermal Addition of Alkanes to Alkenes, IV. Regioselectivity in the Addition of Cyclohexane to 1,2-Disubstituted Alkenes

Alkanes can be added to alkenes in a free radical chain reaction ("ane reaction").Regioselectivity in the addition of cyclohexane to (E)-3-alkyl substituted methyl acrylates have been measured at 300-450C.The ratio of the two regioisomers 3 and 4 shows a correlation with steric substituent constants Es.Relative rates of the addition of cyclohexyl radical to the alkene and β-scission of the adduct radical versus H-transfer from cyclohexane are determining the ratio of the regioisomers.A minor temperature dependence of regioselectivity has been observed.In relation to the products 3 and 4, ane reaction at a temperature of 450C can be more selective than radical addition reaction at room temperature.Regioselectivity of the addition of cyclohexane to methyl cinnamate at 360-420C shows a slight polar substituent effect.Electron withdrawing substituents have been shown to increase product ratio 4/3.

HOCHDRUCK-HOCHTEMPERATUR-REAKTIONEN IN EINEM STROEMUNGSREAKTOR-VI. THERMISCHE ADDITION VON ALKANEN AN ALKENE

The thermal Anti-Markownikow-addition of alkanes to activated and desactivated alkenes ("direkte substituierende Addition", "Ane-reaction") at 650-723 K and reaction times of 1-10 min. is described.