40570-67-0Relevant academic research and scientific papers
Copper/Persulfate-Promoted Oxidative Decarboxylative C?H Acylation of Pyrazolones with α-Oxocarboxylic Acids: Direct Access to 4-Acylpyrazolones under Mild Conditions
Kittikool, Tanakorn,Thupyai, Akkharaphong,Phomphrai, Khamphee,Yotphan, Sirilata
, p. 3345 - 3355 (2018/09/10)
A facile and efficient oxidative C?H acylation of N-substituted pyrazolones using α-oxocarboxylic acids as an acyl group source was developed. A combination of Cu(OAc)2 and K2S2O8 enables the reaction to proceed smoothly under air and provides a wide array of 4-acylpyrazolone products in moderate to excellent yields. The mechanism of this transformation is believed to proceed via a copper-induced decarboxylation to form the acyl-copper species. This method provides a convenient and useful route for a direct installation of an acyl moiety into bioactive pyrazolone derivatives, which can be further utilized in many applications. (Figure presented.).
On the methylation of pyrazolones
Holzer, Wolfgang,Plagens, Brigitte
, p. 455 - 462 (2007/10/03)
Reaction of a series of 1,2-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-ones having a COR substituent (R = Me, Ph, 2-thienyl, CH2CH2Ph, CN = CHPh) in 4-position of the pyrazole ring (tautomer with 4-substituted 5-hydroxy-3-methyl-1-phenyl
