407-47-6

Usage

Uses

Used in Adhesive Industry:
2,2,2-Trifluoroethyl acrylate is used as a component in the formulation of adhesives for its peeling property, which enhances the performance and usability of the adhesive products.
Used in Contact Lens Industry:
In the contact lens industry, 2,2,2-Trifluoroethyl acrylate is utilized as a material to impart antifouling properties to the lenses, ensuring better comfort and vision for the users.
Used in Pharmaceutical Industry:
2,2,2-Trifluoroethyl acrylate serves as a valuable pharmaceutical intermediate, playing a crucial role in the synthesis of various drugs and medications, contributing to the development of novel therapeutics.

InChI:InChI=1/C4H2F6/c5-3(6,7)1-2-4(8,9)10/h1-2H/b2-1+

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 814-68-6 acryloyl chloride 
• 79-10-7 acrylic acid 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 

Downstream Products

• 144261-72-3 3-phenyl-3-hydroxy-2-methylene-propanoic acid 2,2,2-trifluoroethyl ester 
• 891862-16-1 (1S)-cyclohex-3-enecarboxylic acid 2,2,2-trifluoro-ethyl ester 

Relevant academic research and scientific papers

Liberation of acrylates from nickelalactones via Ni─O ring opening with alkyl iodides

The utilization of carbon dioxide as a feedstock for the production of raw chemicals is of high current industrial interest. One attractive reaction is the transformation of carbon dioxide into acrylic acid or acrylates. The cleavage of the Ni─O bond of nickelalactones may result in the formation of acrylates. In this work, C2H5I, CF3CH2I and CF3I are studied as alkylation reagents for the Ni─O ring opening of nickelalactones. The results indicate that both C2H5I and CF3CH2I are able to release acrylates from nickelalactones. Based on the experimental evidence and literature precedents, a mechanism – proceeding via Ni─O ring opening of nickelalactone, β-H elimination to release the acrylate and reductive elimination for recovery of the Ni(0) species – is proposed.

The 'Baylis - Hillman reaction' mechanism and applications revisited

It is shown that reaction of aryl, benzyl, alkyl and functionalised alkyl acrylic esters with benzaldehyde, in the presence of 1,4-diazabicyclo[2.2.2] octane, strongly depends upon the electronic and steric effects of the ester part. This influence is also observed in condensation of furfuraldehyde. Moreover, for the first time, it is shown that the overall condensation is equilibrated.